Epidemiological and genetic analysis concerning the coxsackievirus A6 related endemic outbreak of hand-foot-mouth disease in Taizhou, China, during 2013.
J Med Virol
; 87(12): 2000-8, 2015 Dec.
Article
em En
| MEDLINE
| ID: mdl-25989289
ABSTRACT
A total of 1,098 strains of human enteroviruses (HEV), falling into 14 serotypes were detected upon analysis of 1,509 hand-foot-mouth disease (HFMD) samples collected in Taizhou during the period from July 2010 to December 2013. And a CV-A6 related HFMD outbreak was identified in Taizhou during 2013. Phylogenic analyses of complete VP1 sequences indicate that this outbreak of HFMD in Taizhou is closely related to the global outbreaks of CV-A6 related HFMD since 2008, but the analyses also indicate that the outbreak in Taizhou is rather an endemic outbreak in which a phylogenic sub-group of CV-A6 was identified whose members commonly acquired a mutation RâK at site 254 of VP1 protein. It is interesting that the emergence of the sub-group was inferred to contribute to the endemic outbreak in Taizhou in 2013.
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Surtos de Doenças
/
Enterovirus
/
Genótipo
/
Doença de Mão, Pé e Boca
Limite:
Humans
País/Região como assunto:
Asia
Idioma:
En
Revista:
J Med Virol
Ano de publicação:
2015
Tipo de documento:
Article