Prospective cohort study with active surveillance for fever in four dengue endemic countries in Latin America.
Am J Trop Med Hyg
; 93(1): 18-23, 2015 Jul.
Article
em En
| MEDLINE
| ID: mdl-26013373
ABSTRACT
To prepare for a Phase III dengue vaccine efficacy trial, 20 investigational sites were selected for this observational study to identify dengue infections in a closed cohort (N = 3,000 children 9-16 years of age). Of 255 acute febrile episodes experienced by 235 children, 50 (21.3%) were considered serologically probable dengue, and 18 (7.7%) were considered virologically confirmed (i.e., dengue NS1 antigen positive) dengue cases. Considering the disease-free and at-risk period from study start to onset of symptoms, the overall incidence density of acute febrile episodes was 17.7 per 100 person-years of follow-up, ranging from 15.3 in Colombia to 22.0 in Puerto Rico. This study showed that all sites were capable of capturing and following up acute febrile episodes within a specific timeframe among the established cohort and to detect dengue cases.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Doenças Endêmicas
/
Dengue
/
Vírus da Dengue
/
Febre
/
Anticorpos Antivirais
/
Antígenos Virais
Tipo de estudo:
Etiology_studies
/
Incidence_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
/
Screening_studies
Limite:
Adolescent
/
Child
/
Female
/
Humans
/
Male
País/Região como assunto:
America do sul
/
Brasil
/
Caribe
/
Colombia
/
Mexico
/
Puerto rico
Idioma:
En
Revista:
Am J Trop Med Hyg
Ano de publicação:
2015
Tipo de documento:
Article