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MuSK autoantibodies in myasthenia gravis detected by cell based assay--A multinational study.
Tsonis, A I; Zisimopoulou, P; Lazaridis, K; Tzartos, J; Matsigkou, E; Zouvelou, V; Mantegazza, R; Antozzi, C; Andreetta, F; Evoli, A; Deymeer, F; Saruhan-Direskeneli, G; Durmus, H; Brenner, T; Vaknin, A; Berrih-Aknin, S; Behin, A; Sharshar, T; De Baets, M; Losen, M; Martinez-Martinez, P; Kleopa, K A; Zamba-Papanicolaou, E; Kyriakides, T; Kostera-Pruszczyk, A; Szczudlik, P; Szyluk, B; Lavrnic, D; Basta, I; Peric, S; Tallaksen, C; Maniaol, A; Casasnovas Pons, C; Pitha, J; Jakubíkova, M; Hanisch, F; Tzartos, S J.
Afiliação
  • Tsonis AI; Hellenic Pasteur Institute, Athens, Greece; University of Patras, Patras, Greece.
  • Zisimopoulou P; Hellenic Pasteur Institute, Athens, Greece. Electronic address: zisimopoulou@pasteur.gr.
  • Lazaridis K; Hellenic Pasteur Institute, Athens, Greece.
  • Tzartos J; Hellenic Pasteur Institute, Athens, Greece.
  • Matsigkou E; Hellenic Pasteur Institute, Athens, Greece.
  • Zouvelou V; Neurology Department, Aeginition Hospital, Athens, Greece.
  • Mantegazza R; Neurological Institute "C. Besta", Milano, Italy.
  • Antozzi C; Neurological Institute "C. Besta", Milano, Italy.
  • Andreetta F; Neurological Institute "C. Besta", Milano, Italy.
  • Evoli A; Institute of Neurology, Catholic University, Rome, Italy.
  • Deymeer F; Istanbul University, Istanbul, Turkey.
  • Saruhan-Direskeneli G; Istanbul University, Istanbul, Turkey.
  • Durmus H; Istanbul University, Istanbul, Turkey.
  • Brenner T; Hadassah Hebrew University Medical Center, Jerusalem, Israel.
  • Vaknin A; Hadassah Hebrew University Medical Center, Jerusalem, Israel.
  • Berrih-Aknin S; UPMC and INSERM, Paris, France.
  • Behin A; UPMC and INSERM, Paris, France.
  • Sharshar T; Raymond Poincaré Hospital, Garches, France.
  • De Baets M; School for Mental Health and Neuroscience, Maastricht University, The Netherlands.
  • Losen M; School for Mental Health and Neuroscience, Maastricht University, The Netherlands.
  • Martinez-Martinez P; School for Mental Health and Neuroscience, Maastricht University, The Netherlands.
  • Kleopa KA; The Cyprus Institute of Neurology and Genetics, Nicosia, Cyprus.
  • Zamba-Papanicolaou E; The Cyprus Institute of Neurology and Genetics, Nicosia, Cyprus.
  • Kyriakides T; The Cyprus Institute of Neurology and Genetics, Nicosia, Cyprus.
  • Kostera-Pruszczyk A; Department of Neurology, Medical University of Warsaw, Poland.
  • Szczudlik P; Department of Neurology, Medical University of Warsaw, Poland.
  • Szyluk B; Department of Neurology, Medical University of Warsaw, Poland.
  • Lavrnic D; Neurology Clinic, Clinical Center of Serbia, School of Medicine, University of Belgrade, Belgrade, Serbia.
  • Basta I; Neurology Clinic, Clinical Center of Serbia, School of Medicine, University of Belgrade, Belgrade, Serbia.
  • Peric S; Neurology Clinic, Clinical Center of Serbia, School of Medicine, University of Belgrade, Belgrade, Serbia.
  • Tallaksen C; Norway Department of Neurology, Ullevaal University Hospital, Oslo, Norway; Faculty of Medicine, Olso University, Norway.
  • Maniaol A; Norway Department of Neurology, Ullevaal University Hospital, Oslo, Norway.
  • Casasnovas Pons C; Bellvitge University Hospital, Barcelona, Spain.
  • Pitha J; Department of Neurology and Clinical Neuroscience Center, 1st Faculty of Medicine, Charles University and General Teaching Hospital, Prague, Czech Republic.
  • Jakubíkova M; Department of Neurology and Clinical Neuroscience Center, 1st Faculty of Medicine, Charles University and General Teaching Hospital, Prague, Czech Republic.
  • Hanisch F; Universitätsklinikum Halle, Germany.
  • Tzartos SJ; Hellenic Pasteur Institute, Athens, Greece; University of Patras, Patras, Greece; Tzartos NeuroDiagnostics, Athens, Greece. Electronic address: tzartos@pasteur.gr.
J Neuroimmunol ; 284: 10-7, 2015 Jul 15.
Article em En | MEDLINE | ID: mdl-26025053
ABSTRACT
Seronegative myasthenia gravis (MG) presents a serious gap in MG diagnosis and understanding. We applied a cell based assay (CBA) for the detection of muscle specific kinase (MuSK) antibodies undetectable by radioimmunoassay. We tested 633 triple-seronegative MG patients' sera from 13 countries, detecting 13% as positive. MuSK antibodies were found, at significantly lower frequencies, in 1.9% of healthy controls and 5.1% of other neuroimmune disease patients, including multiple sclerosis and neuromyelitis optica. The clinical data of the newly diagnosed MuSK-MG patients are presented. 27% of ocular seronegative patients were MuSK antibody positive. Moreover, 23% had thymic hyperplasia suggesting that thymic abnormalities are more common than believed.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Autoanticorpos / Receptores Proteína Tirosina Quinases / Miastenia Gravis Tipo de estudo: Diagnostic_studies Limite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: J Neuroimmunol Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Grécia
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Autoanticorpos / Receptores Proteína Tirosina Quinases / Miastenia Gravis Tipo de estudo: Diagnostic_studies Limite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: J Neuroimmunol Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Grécia