Betulinic Acid and its Derivatives as Potential Antitumor Agents.
Med Res Rev
; 35(6): 1127-55, 2015 Nov.
Article
em En
| MEDLINE
| ID: mdl-26032847
ABSTRACT
Betulinic acid (BA) is a lupane-type pentacyclic triterpene, distributed ubiquitously throughout the plant kingdom. BA and its derivatives demonstrate multiple bioactivities, particularly an antitumor effect. This review critically describes the recent research on isolation, synthesis, and derivatization of BA and its natural analogs betulin and 23-hydroxybetulinic acid. The subsequent part of the review focuses on the current knowledge of antitumor properties, combination treatments, and pharmacological mechanisms of these compounds. A 3D-QSAR analysis of 62 BA derivatives against human ovarian cancer A2780 is also included to provide information concerning the structure-cytotoxicity relationships of these compounds.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Triterpenos
/
Antineoplásicos
Limite:
Humans
Idioma:
En
Revista:
Med Res Rev
Ano de publicação:
2015
Tipo de documento:
Article