Heat treatment inhibits skeletal muscle atrophy of glucocorticoid-induced myopathy in rats.
Physiol Res
; 64(6): 897-905, 2015.
Article
em En
| MEDLINE
| ID: mdl-26047372
ABSTRACT
The purpose of this study was to investigate the influence of heat treatment on glucocorticoid (GC)-induced myopathy. Eight-week-old Wistar rats were randomly assigned to the control, Dex, and Dex + Heat groups. Dexamethasone (2 mg/kg) was injected subcutaneously 6 days per week for 2 weeks in the Dex and Dex + Heat group. In the Dex + Heat group, heat treatment was performed by immersing hindlimbs in water at 42 °C for 60 min, once every 3 days for 2 weeks. The extensor digitorum longus muscle was extracted following 2 weeks of experimentation. In the Dex + Heat group, muscle fiber diameter, capillary/muscle fiber ratio, and level of heat shock protein 72 were significantly higher and atrogene expression levels were significantly lower than in the Dex group. Our results suggest that heat treatment inhibits the development of GC-induced myopathy by decreasing atrogene expression and increasing angiogenesis.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Dexametasona
/
Atrofia Muscular
/
Glucocorticoides
/
Temperatura Alta
/
Doenças Musculares
Tipo de estudo:
Etiology_studies
/
Evaluation_studies
Limite:
Animals
Idioma:
En
Revista:
Physiol Res
Assunto da revista:
FISIOLOGIA
Ano de publicação:
2015
Tipo de documento:
Article
País de afiliação:
Japão