Leucine-Rich Repeat Kinase 2 (Lrrk2) Deficiency Diminishes the Development of Experimental Autoimmune Uveitis (EAU) and the Adaptive Immune Response.

Wandu, Wambui S; Tan, Cuiyan; Ogbeifun, Osato; Vistica, Barbara P; Shi, Guangpu; Hinshaw, Samuel J H; Xie, Chengsong; Chen, Xi; Klinman, Dennis M; Cai, Huaibin; Gery, Igal

Wandu, Wambui S; Tan, Cuiyan; Ogbeifun, Osato; Vistica, Barbara P; Shi, Guangpu; Hinshaw, Samuel J H; Xie, Chengsong; Chen, Xi; Klinman, Dennis M; Cai, Huaibin; Gery, Igal.

Afiliação

Wandu WS; Laboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, MD, 20892, United States of America.
Tan C; Laboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, MD, 20892, United States of America.
Ogbeifun O; Laboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, MD, 20892, United States of America.
Vistica BP; Laboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, MD, 20892, United States of America.
Shi G; Laboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, MD, 20892, United States of America.
Hinshaw SJ; Laboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, MD, 20892, United States of America.
Xie C; Transgenic Section, Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, 20892, United States of America.
Chen X; Transgenic Section, Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, 20892, United States of America.
Klinman DM; Cancer and Inflammation Program, National Cancer Institute, National Institutes of Health, Frederick, MD, 21702, United States of America.
Cai H; Transgenic Section, Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, 20892, United States of America.
Gery I; Laboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, MD, 20892, United States of America.

PLoS One ; 10(6): e0128906, 2015.

Article em En | MEDLINE | ID: mdl-26067490

Assuntos

Doenças Autoimunes/patologia; Proteínas Serina-Treonina Quinases/genética; Uveíte/patologia; Imunidade Adaptativa; Animais; Doenças Autoimunes/metabolismo; Quimiocinas/metabolismo; Modelos Animais de Doenças; Proteínas do Olho/imunologia; Fatores de Transcrição Forkhead/metabolismo; Hipersensibilidade Tardia/etiologia; Hipersensibilidade Tardia/imunologia; Interferon gama/metabolismo; Interleucina-17/metabolismo; Serina-Treonina Proteína Quinase-2 com Repetições Ricas em Leucina; Macrófagos Peritoneais/imunologia; Macrófagos Peritoneais/metabolismo; Camundongos; Camundongos Endogâmicos C57BL; Camundongos Knockout; Proteínas Serina-Treonina Quinases/deficiência; Proteínas de Ligação ao Retinol/imunologia; Testes Cutâneos; Células Th1/citologia; Células Th1/imunologia; Células Th1/metabolismo; Células Th17/citologia; Células Th17/imunologia; Células Th17/metabolismo; Uveíte/metabolismo

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doenças Autoimunes / Uveíte / Proteínas Serina-Treonina Quinases Tipo de estudo: Etiology_studies / Prognostic_studies Limite: Animals Idioma: En Revista: PLoS One Assunto da revista: CIENCIA / MEDICINA Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Estados Unidos

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