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Mitochondrial responsibility in ageing process: innocent, suspect or guilty.
López-Lluch, Guillermo; Santos-Ocaña, Carlos; Sánchez-Alcázar, José Antonio; Fernández-Ayala, Daniel José Moreno; Asencio-Salcedo, Claudio; Rodríguez-Aguilera, Juan Carlos; Navas, Plácido.
Afiliação
  • López-Lluch G; Centro Andaluz de Biología del Desarrollo, CABD-CSIC, CIBERER, Instituto Carlos III, Universidad Pablo de Olavide, Carretera de Utrera km. 1, 41013, Seville, Spain, glopllu@upo.es.
Biogerontology ; 16(5): 599-620, 2015 Oct.
Article em En | MEDLINE | ID: mdl-26105157
ABSTRACT
Ageing is accompanied by the accumulation of damaged molecules in cells due to the injury produced by external and internal stressors. Among them, reactive oxygen species produced by cell metabolism, inflammation or other enzymatic processes are considered key factors. However, later research has demonstrated that a general mitochondrial dysfunction affecting electron transport chain activity, mitochondrial biogenesis and turnover, apoptosis, etc., seems to be in a central position to explain ageing. This key role is based on several effects from mitochondrial-derived ROS production to the essential maintenance of balanced metabolic activities in old organisms. Several studies have demonstrated caloric restriction, exercise or bioactive compounds mainly found in plants, are able to affect the activity and turnover of mitochondria by increasing biogenesis and mitophagy, especially in postmitotic tissues. Then, it seems that mitochondria are in the centre of metabolic procedures to be modified to lengthen life- or health-span. In this review we show the importance of mitochondria to explain the ageing process in different models or organisms (e.g. yeast, worm, fruitfly and mice). We discuss if the cause of aging is dependent on mitochondrial dysfunction of if the mitochondrial changes observed with age are a consequence of events taking place outside the mitochondrial compartment.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Autofagia / Envelhecimento / Estresse Oxidativo / Metabolismo Energético / Mitocôndrias Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Revista: Biogerontology Assunto da revista: GERIATRIA Ano de publicação: 2015 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Autofagia / Envelhecimento / Estresse Oxidativo / Metabolismo Energético / Mitocôndrias Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Revista: Biogerontology Assunto da revista: GERIATRIA Ano de publicação: 2015 Tipo de documento: Article