Bronchoscopic Coil Treatment for Patients with Severe Emphysema: A Meta-Analysis.
Respiration
; 90(2): 136-45, 2015.
Article
em En
| MEDLINE
| ID: mdl-26112380
ABSTRACT
BACKGROUND:
Bronchoscopic coil treatment has been shown to improve pulmonary function, exercise capacity, and quality of life in patients with severe emphysema.OBJECTIVES:
To perform a meta-analysis of the results of four independent European clinical trials investigating this coil therapy for emphysema.METHODS:
Data on all patients included in the four European clinical trials were analyzed for efficacy and safety outcomes.RESULTS:
A total of 2,536 coils were placed during 259 procedures in 140 patients. A total of 37 chronic obstructive pulmonary disease exacerbations and 27 pneumonias were recorded as serious adverse events up to 1 year after treatment. The pneumothorax rate was 6.4%. Both 6 and 12 months after treatment, significant (all p < 0.001) improvements were observed for forced expiratory volume in 1 s [+0.08 liters (±0.19) and +0.08 liters (±0.21)], residual volume [RV; -510 ml (±850) and -430 ml (±720)], 6-min walking distance [6MWD; +44.1 m (±69.8) and +38.1 m (±71.9)], and St. George's Respiratory Questionnaire score [SGRQ; -9.5 points (±14.3) and -7.7 points (±14.2)]. No differences in any outcome measures were observed between heterogeneous and homogeneous emphysema patients. Only a high baseline RV was found to be an independent predictor of successful treatment.CONCLUSIONS:
Bronchoscopic coil treatment improves pulmonary function, 6MWD, and quality of life in patients with severe emphysema up to 1 year after treatment, independent of the distribution of the disease.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Pneumonectomia
/
Enfisema Pulmonar
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Broncoscopia
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Doença Pulmonar Obstrutiva Crônica
Tipo de estudo:
Diagnostic_studies
/
Etiology_studies
/
Prognostic_studies
/
Systematic_reviews
Limite:
Aged
/
Female
/
Humans
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Male
/
Middle aged
Idioma:
En
Revista:
Respiration
Ano de publicação:
2015
Tipo de documento:
Article
País de afiliação:
Holanda