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Microenvironment and HIV-related lymphomagenesis.
Pantanowitz, Liron; Carbone, Antonino; Dolcetti, Riccardo.
Afiliação
  • Pantanowitz L; Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA, USA. Electronic address: pantanowitzl@upmc.edu.
  • Carbone A; Department of Pathology, Centro di Riferimento Oncologico, IRCCS, National Cancer Institute, Aviano, PN, Italy.
  • Dolcetti R; Cancer Bio-Immunotherapy Unit, Centro di Riferimento Oncologico, IRCCS, National Cancer Institute, Aviano, PN, Italy.
Semin Cancer Biol ; 34: 52-7, 2015 Oct.
Article em En | MEDLINE | ID: mdl-26118690
Patients with HIV infection are at increased risk of developing non-Hodgkin lymphoma and Hodgkin lymphoma. While the pathogenesis of these lymphomas is incompletely understood, evidence indicates that immune deregulation, genetic alterations and cytokine production play an important role in HIV lymphomagenesis. The lymphoma microenvironment in this heterogeneous group of lymphomas plays an equally critical role in their development, growth and progression. Important components of the microenvironment in HIV-related lymphomas include EBV and/or HHV-8 coinfection, reactive inflammatory cells, tumor microvasculature, and soluble factors. This paper provides a brief overview of HIV-related lymphomas and focuses on their lymphomagenesis and microenvironment.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Linfoma Relacionado a AIDS / Microambiente Tumoral Tipo de estudo: Diagnostic_studies Limite: Animals / Humans Idioma: En Revista: Semin Cancer Biol Assunto da revista: NEOPLASIAS Ano de publicação: 2015 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Linfoma Relacionado a AIDS / Microambiente Tumoral Tipo de estudo: Diagnostic_studies Limite: Animals / Humans Idioma: En Revista: Semin Cancer Biol Assunto da revista: NEOPLASIAS Ano de publicação: 2015 Tipo de documento: Article