Brain activity mapping at multiple scales with silicon microprobes containing 1,024 electrodes.
J Neurophysiol
; 114(3): 2043-52, 2015 Sep.
Article
em En
| MEDLINE
| ID: mdl-26133801
ABSTRACT
The coordinated activity of neural ensembles across multiple interconnected regions has been challenging to study in the mammalian brain with cellular resolution using conventional recording tools. For instance, neural systems regulating learned behaviors often encompass multiple distinct structures that span the brain. To address this challenge we developed a three-dimensional (3D) silicon microprobe capable of simultaneously measuring extracellular spike and local field potential activity from 1,024 electrodes. The microprobe geometry can be precisely configured during assembly to target virtually any combination of four spatially distinct neuroanatomical planes. Here we report on the operation of such a device built for high-throughput monitoring of neural signals in the orbitofrontal cortex and several nuclei in the basal ganglia. We perform analysis on systems-level dynamics and correlations during periods of conditioned behavioral responding and rest, demonstrating the technology's ability to reveal functional organization at multiple scales in parallel in the mouse brain.
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Gânglios da Base
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Mapeamento Encefálico
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Eletroencefalografia
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Lobo Frontal
Limite:
Animals
Idioma:
En
Revista:
J Neurophysiol
Ano de publicação:
2015
Tipo de documento:
Article