Pancreatic regeneration: basic research and gene regulation.
Surg Today
; 46(6): 633-40, 2016 Jun.
Article
em En
| MEDLINE
| ID: mdl-26148809
ABSTRACT
Pancreatic regeneration (PR) is an interesting phenomenon that could provide clues as to how the control of diabetes mellitus might be achieved. Due to the different regenerative abilities of the pancreas and liver, the molecular mechanism responsible for PR is largely unknown. In this review, we describe five representative murine models of PR and thirteen humoral mitogens that stimulate ß-cell proliferation. We also describe pancreatic ontogenesis, including the molecular transcriptional differences between α-cells and ß-cells. Furthermore, we review 14 murine models which carry defects in genes related to key transcription factors for pancreatic ontogenesis to gain further insight into pancreatic development.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Pâncreas
/
Regeneração
/
Fatores de Transcrição
/
Peptídeos e Proteínas de Sinalização Intercelular
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Fator de Crescimento Epidérmico
/
Incretinas
Tipo de estudo:
Prognostic_studies
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Surg Today
Ano de publicação:
2016
Tipo de documento:
Article
País de afiliação:
Japão