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HLA class I as a predictor of clinical prognosis and CTL infiltration as a predictor of chemosensitivity in ovarian cancer.
Hirohashi, Yoshihiko; Torigoe, Toshihiko; Mariya, Tasuku; Kochin, Vitaly; Saito, Tsuyoshi; Sato, Noriyuki.
Afiliação
  • Hirohashi Y; Department of Pathology; Sapporo Medical University School of Medicine ; Sapporo, Japan.
  • Torigoe T; Department of Pathology; Sapporo Medical University School of Medicine ; Sapporo, Japan.
  • Mariya T; Department of Pathology; Sapporo Medical University School of Medicine ; Sapporo, Japan ; Department of Obstetrics and Gynecology; Sapporo Medical University School of Medicine ; Sapporo, Japan.
  • Kochin V; Department of Pathology; Sapporo Medical University School of Medicine ; Sapporo, Japan.
  • Saito T; Department of Obstetrics and Gynecology; Sapporo Medical University School of Medicine ; Sapporo, Japan.
  • Sato N; Department of Pathology; Sapporo Medical University School of Medicine ; Sapporo, Japan.
Oncoimmunology ; 4(5): e1005507, 2015 May.
Article em En | MEDLINE | ID: mdl-26155404
Cytotoxic T lymphocytes (CTLs) recognize the human leukocyte antigen (HLA) class I and antigenic peptide complex, and they play a crucial role in cancer immunity. Our recent study revealed that HLA class I downregulation is related to poorer prognosis and a low level of intratumoral CTLs is associated with platinum resistance, indicating the significance of immunological surveillance.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Prognostic_studies / Risk_factors_studies Idioma: En Revista: Oncoimmunology Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Japão
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Prognostic_studies / Risk_factors_studies Idioma: En Revista: Oncoimmunology Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Japão