Identification of activating enzymes of a novel FBPase inhibitor prodrug, CS-917.

Kubota, Kazuishi; Inaba, Shin-Ichi; Nakano, Rika; Watanabe, Mihoko; Sakurai, Hidetaka; Fukushima, Yumiko; Ichikawa, Kimihisa; Takahashi, Tohru; Izumi, Takashi; Shinagawa, Akira

Kubota, Kazuishi; Inaba, Shin-Ichi; Nakano, Rika; Watanabe, Mihoko; Sakurai, Hidetaka; Fukushima, Yumiko; Ichikawa, Kimihisa; Takahashi, Tohru; Izumi, Takashi; Shinagawa, Akira.

Afiliação

Kubota K; Discovery Science and Technology Department, Daiichi Sankyo RD Novare Co., Ltd. Tokyo, Japan.
Inaba S; Drug Metabolism & Pharmacokinetics Research Laboratories, Daiichi Sankyo Co., Ltd. Tokyo, Japan.
Nakano R; Discovery Science and Technology Department, Daiichi Sankyo RD Novare Co., Ltd. Tokyo, Japan.
Watanabe M; Discovery Science and Technology Department, Daiichi Sankyo RD Novare Co., Ltd. Tokyo, Japan.
Sakurai H; Discovery Science and Technology Department, Daiichi Sankyo RD Novare Co., Ltd. Tokyo, Japan.
Fukushima Y; Discovery Science and Technology Department, Daiichi Sankyo RD Novare Co., Ltd. Tokyo, Japan.
Ichikawa K; Biologics Technology Research Laboratories, Daiichi Sankyo Co., Ltd. Tokyo, Japan.
Takahashi T; New Modality Research Laboratories, Daiichi Sankyo Co., Ltd. Tokyo, Japan.
Izumi T; Drug Metabolism & Pharmacokinetics Research Laboratories, Daiichi Sankyo Co., Ltd. Tokyo, Japan.
Shinagawa A; Discovery Science and Technology Department, Daiichi Sankyo RD Novare Co., Ltd. Tokyo, Japan.

Pharmacol Res Perspect ; 3(3): e00138, 2015 Jun.

Article em En | MEDLINE | ID: mdl-26171222

Palavras-chave

Biochemical purification; CS-917; FBPase inhibitor; bisamidate prodrug; drug metabolizing enzyme; phosphoramidase

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Diagnostic_studies Idioma: En Revista: Pharmacol Res Perspect Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Japão

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