Central nervous effects of a new tricyclic antidepressant (amitriptylinoxide).
Arzneimittelforschung
; 28(10b): 1874-9, 1978.
Article
em En
| MEDLINE
| ID: mdl-261811
ABSTRACT
The central action of amitriptylinoxide was investigated in mice and rats using established models. The substance was found to possess antidepressant, drive-promoting properties which correspond to amitriptyline in their intensity or are superior even. In addition the pharmacodynamic spectrum of amitriptylinoxide displays a sedative component that is considered a desirable accompanying effect but is somewhat weaker than with amitriptyline. According to revealed differences in this work between the pharmacological activities of amitripytlinoxide and those of other tricyclic antidepressants, it became reasonable to undertake further studies to investigate its main and side effects.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Sistema Nervoso Central
/
Amitriptilina
Limite:
Animals
/
Humans
/
Male
Idioma:
En
Revista:
Arzneimittelforschung
Ano de publicação:
1978
Tipo de documento:
Article