Sickle Cell Hemoglobin with Mutation at &#945;His-50 Has Improved Solubility.

Tam, Ming F; Tam, Tsuey Chyi S; Simplaceanu, Virgil; Ho, Nancy T; Zou, Ming; Ho, Chien

Sickle Cell Hemoglobin with Mutation at αHis-50 Has Improved Solubility.

Tam, Ming F; Tam, Tsuey Chyi S; Simplaceanu, Virgil; Ho, Nancy T; Zou, Ming; Ho, Chien.

Afiliação

Tam MF; From the Department of Biological Sciences, Carnegie Mellon University, Pittsburgh, Pennsylvania 15213.
Tam TC; From the Department of Biological Sciences, Carnegie Mellon University, Pittsburgh, Pennsylvania 15213.
Simplaceanu V; From the Department of Biological Sciences, Carnegie Mellon University, Pittsburgh, Pennsylvania 15213.
Ho NT; From the Department of Biological Sciences, Carnegie Mellon University, Pittsburgh, Pennsylvania 15213.
Zou M; From the Department of Biological Sciences, Carnegie Mellon University, Pittsburgh, Pennsylvania 15213.
Ho C; From the Department of Biological Sciences, Carnegie Mellon University, Pittsburgh, Pennsylvania 15213 chienho@andrew.cmu.edu.

J Biol Chem ; 290(35): 21762-72, 2015 Aug 28.

Article em En | MEDLINE | ID: mdl-26187468

Assuntos

Hemoglobina Falciforme/genética; Hemoglobina Falciforme/metabolismo; Mutação/genética; Hemoglobina Falciforme/química; Histidina/genética; Humanos; Cinética; Oxirredução; Oxigênio/metabolismo; Polimerização; Espectroscopia de Prótons por Ressonância Magnética; Proteínas Recombinantes/química; Proteínas Recombinantes/genética; Solubilidade; Temperatura

Palavras-chave

Csat; autoxidation; hemoglobin; mutant; nuclear magnetic resonance (NMR); oxygen binding; protein stability; sickle cell

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Hemoglobina Falciforme / Mutação Limite: Humans Idioma: En Revista: J Biol Chem Ano de publicação: 2015 Tipo de documento: Article

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