Lipidomics in drug development.
Drug Discov Today Technol
; 13: 33-8, 2015 Jun.
Article
em En
| MEDLINE
| ID: mdl-26190681
ABSTRACT
Numerous human pathologies, including common conditions such as obesity, diabetes, cardiovascular disease, cancer, inflammatory disease and neurodegeneration, involve changes in lipid metabolism. Likewise, a growing number of drugs are being developed that directly or indirectly affect lipid metabolic pathways. Instead of classical and cumbrous radiochemical analyses, lipid profiling by mass spectrometry (MS)-based lipidomics holds great potential as companion diagnostic in several steps along the drug development process. In this review we describe some typical lipidomics set-ups and illustrate how these technologies can be implemented in target discovery, compound screening, in vitro and in vivo preclinical testing, toxicity testing of drugs, and prediction and monitoring of response.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Metabolismo dos Lipídeos
/
Descoberta de Drogas
/
Metabolômica
Limite:
Humans
Idioma:
En
Revista:
Drug Discov Today Technol
Ano de publicação:
2015
Tipo de documento:
Article
País de afiliação:
Bélgica