Combined immunodeficiency in the United States and Kuwait: Comparison of patients' characteristics and molecular diagnosis.
Clin Immunol
; 161(2): 170-3, 2015 Dec.
Article
em En
| MEDLINE
| ID: mdl-26248333
ABSTRACT
AIM:
To compare different variables among (S)CID patients diagnosed in the USA and Kuwait.METHODS:
Review of patients registered in The US Immune Deficiency Network registry or Kuwait National PID Registry between 2004 and 2014.RESULTS:
Totals of 98 and 69 (S)CID patients were registered during the study period in the USIDNET registry and the KNPIDR, respectively. The average annual incidence rate for the period 2004-2014 of (S)CID in children in Kuwait was 13.01/100,000 children, with an estimated occurrence of 1/7500 live births. There were differences between the two countries in the following variables age at onset and diagnosis, family history of (S)CID, parental consanguinity, and outcome. More than 14% of (S)CID patients from USIDNET registry were diagnosed through newborn screening.CONCLUSIONS:
Patients' characteristics and molecular causes of S(CID) are different between USA and Kuwait. NBS for SCID should be started in countries where the incidence of (S)CID is high.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Síndromes de Imunodeficiência
Tipo de estudo:
Diagnostic_studies
Limite:
Child
/
Humans
/
Newborn
País/Região como assunto:
America do norte
/
Asia
Idioma:
En
Revista:
Clin Immunol
Assunto da revista:
ALERGIA E IMUNOLOGIA
Ano de publicação:
2015
Tipo de documento:
Article