[Studies on DNA methylation in transformed mouse liver cells].
Shi Yan Sheng Wu Xue Bao
; 22(4): 417-21, 1989 Dec.
Article
em Zh
| MEDLINE
| ID: mdl-2626895
ABSTRACT
Activity of DNA methylase and DNA methylation level were measured from normal mouse liver, mouse liver charged with H22a ascitic hepatoma and H22a ascitic hepatoma cell by measuring incorporation of H3-methyl. S-Adenosyl-3H-methyl-methionine (3H-SAM) was used as methyl donor. DNA methylation level of different cells were measured by HP-LC. DNA methylase activity and DNA methylation level of H22a ascitic hepatoma, mouse liver charged with H22a ascitic hepatoma are lower than normal mouse liver. Treatments of antitumor drugs lead to a rising of DNA methylase activity of tumor cell, however, the DNA methylation level of tumor cell has not rised after such treatments.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Metilases de Modificação do DNA
/
Neoplasias Hepáticas Experimentais
Limite:
Animals
Idioma:
Zh
Revista:
Shi Yan Sheng Wu Xue Bao
Ano de publicação:
1989
Tipo de documento:
Article