Outcomes of pregnancies with more than one positive prenatal screening result in the first or second trimester.
Prenat Diagn
; 35(12): 1223-31, 2015 Dec.
Article
em En
| MEDLINE
| ID: mdl-26288069
ABSTRACT
OBJECTIVE:
To describe adverse outcomes and fetal abnormalities in women with a positive prenatal screening result for more than one disorder. STUDYDESIGN:
Study participants were drawn from a population of 452 901 women pregnant with singletons entering the California Prenatal Screening Program in their first-trimester. Risk assessment was provided for trisomy 21 and trisomy 18 in the first-trimester and trisomy 21, trisomy 18, neural tube defects, and Smith-Lemli-Opitz syndrome in the second-trimester. Inclusion in this study required positive screening for more than one of the screened conditions and a completed outcome of pregnancy survey.RESULTS:
A total of 874 women met our study inclusion criteria. Over 25% of these pregnancies had a fetus with a chromosomal abnormality. Of the euploid pregnancies, 6.9% had a fetus with a major birth defect. Of the pregnancies with a fetus with neither a chromosomal abnormality nor a major birth defect, 9.3% ended in fetal demise. Overall, more than 50% of women with multiple positive screening results had either a fetus with a birth defect or a poor pregnancy outcome.CONCLUSION:
Although it is rare to screen positive for more than one condition, such results indicate a very high risk for chromosomal abnormality, fetal demise, or structural abnormality.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Resultado da Gravidez
/
Transtornos Cromossômicos
/
Testes para Triagem do Soro Materno
Tipo de estudo:
Diagnostic_studies
/
Observational_studies
/
Risk_factors_studies
/
Screening_studies
Limite:
Adult
/
Female
/
Humans
/
Pregnancy
País/Região como assunto:
America do norte
Idioma:
En
Revista:
Prenat Diagn
Ano de publicação:
2015
Tipo de documento:
Article
País de afiliação:
Estados Unidos