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Enzyme-Responsive Nanoparticles for Targeted Accumulation and Prolonged Retention in Heart Tissue after Myocardial Infarction.
Nguyen, Mary M; Carlini, Andrea S; Chien, Miao-Ping; Sonnenberg, Sonya; Luo, Colin; Braden, Rebecca L; Osborn, Kent G; Li, Yiwen; Gianneschi, Nathan C; Christman, Karen L.
Afiliação
  • Nguyen MM; Department of Bioengineering, Sanford Consortium for Regenerative Medicine, University of California, San Diego, La Jolla, CA, 92093, USA.
  • Carlini AS; Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, CA, 92093, USA.
  • Chien MP; Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, CA, 92093, USA.
  • Sonnenberg S; Department of Bioengineering, Sanford Consortium for Regenerative Medicine, University of California, San Diego, La Jolla, CA, 92093, USA.
  • Luo C; Department of Medicine, University of California, San Diego, La Jolla, CA, 92093, USA.
  • Braden RL; Department of Bioengineering, Sanford Consortium for Regenerative Medicine, University of California, San Diego, La Jolla, CA, 92093, USA.
  • Osborn KG; Animal Care Program, University of California, San Diego, La Jolla, CA, 92093, USA.
  • Li Y; Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, CA, 92093, USA.
  • Gianneschi NC; Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, CA, 92093, USA.
  • Christman KL; Department of Bioengineering, Sanford Consortium for Regenerative Medicine, University of California, San Diego, La Jolla, CA, 92093, USA.
Adv Mater ; 27(37): 5547-52, 2015 Oct 07.
Article em En | MEDLINE | ID: mdl-26305446
ABSTRACT
A method for targeting to and retaining intravenously injected nanoparticles at the site of acute myocardial infarction in a rat model is described. Enzyme-responsive peptide-polymer amphiphiles are assembled as spherical micellar nanoparticles, and undergo a morphological transition from spherical-shaped, discrete materials to network-like assemblies when acted upon by matrix metalloproteinases (MMP-2 and MMP-9), which are up-regulated in heart tissue post-myocardial infarction.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Portadores de Fármacos / Metaloproteinase 2 da Matriz / Metaloproteinase 9 da Matriz / Nanopartículas / Coração / Infarto do Miocárdio Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Adv Mater Assunto da revista: BIOFISICA / QUIMICA Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Portadores de Fármacos / Metaloproteinase 2 da Matriz / Metaloproteinase 9 da Matriz / Nanopartículas / Coração / Infarto do Miocárdio Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Adv Mater Assunto da revista: BIOFISICA / QUIMICA Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Estados Unidos