Successful Use of Adalimumab for Treating Pyoderma Gangrenosum with Ulcerative Colitis under Corticosteroid-tapering Conditions.
Intern Med
; 54(17): 2167-72, 2015.
Article
em En
| MEDLINE
| ID: mdl-26328641
ABSTRACT
A 52-year-old woman with ulcerative colitis was admitted to our hospital for an ulcerative colitis flare-up under salazosulfapyridine therapy. The symptoms improved with high-dose corticosteroids. After prednisolone was tapered to 10 mg, the frequency of diarrhea increased. The diarrhea was accompanied by joint pain and a skin ulcer with abscess formation, which was diagnosed to be pyoderma gangrenosum. The patient was started on adalimumab. A positive response to the adalimumab therapy was observed after 2 weeks, during which time the ulcerative skin lesion healed completely, however, colonic mucosal healing was achieved at 2 months. Therefore, adalimumab appears to be an effective therapeutic option for patients with ulcerative colitis-associated pyoderma gangrenosum.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Úlcera Cutânea
/
Prednisolona
/
Colite Ulcerativa
/
Pioderma Gangrenoso
/
Corticosteroides
/
Adalimumab
/
Anti-Inflamatórios
Tipo de estudo:
Etiology_studies
Limite:
Female
/
Humans
/
Middle aged
Idioma:
En
Revista:
Intern Med
Assunto da revista:
MEDICINA INTERNA
Ano de publicação:
2015
Tipo de documento:
Article
País de afiliação:
Japão