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Supracolloidal Assemblies as Sacrificial Templates for Porous Silk-Based Biomaterials.
Hardy, John G; Ghezzi, Chiara E; Saballos, Richard J; Kaplan, David L; Schmidt, Christine E.
Afiliação
  • Hardy JG; J. Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, Biomedical Sciences Building JG-53, P.O. Box 116131, Gainesville, FL 32611-6131, USA. johnhardyuk@gmail.com.
  • Ghezzi CE; Department of Biomedical Engineering, the University of Texas at Austin, Austin, TX 78712, USA. johnhardyuk@gmail.com.
  • Saballos RJ; Department of Biomedical Engineering, Tufts University, Medford, MA 02155, USA. johnhardyuk@gmail.com.
  • Kaplan DL; Department of Biomedical Engineering, Tufts University, Medford, MA 02155, USA. Chiara.Ghezzi@tufts.edu.
  • Schmidt CE; J. Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, Biomedical Sciences Building JG-53, P.O. Box 116131, Gainesville, FL 32611-6131, USA. richardsaballos@live.com.
Int J Mol Sci ; 16(9): 20511-22, 2015 Aug 28.
Article em En | MEDLINE | ID: mdl-26343650
ABSTRACT
Tissues in the body are hierarchically structured composite materials with tissue-specific properties. Urea self-assembles via hydrogen bonding interactions into crystalline supracolloidal assemblies that can be used to impart macroscopic pores to polymer-based tissue scaffolds. In this communication, we explain the solvent interactions governing the solubility of urea and thereby the scope of compatible polymers. We also highlight the role of solvent interactions on the morphology of the resulting supracolloidal crystals. We elucidate the role of polymer-urea interactions on the morphology of the pores in the resulting biomaterials. Finally, we demonstrate that it is possible to use our urea templating methodology to prepare Bombyx mori silk protein-based biomaterials with pores that human dermal fibroblasts respond to by aligning with the long axis of the pores. This methodology has potential for application in a variety of different tissue engineering niches in which cell alignment is observed, including skin, bone, muscle and nerve.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Materiais Biocompatíveis / Seda Limite: Humans Idioma: En Revista: Int J Mol Sci Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Estados Unidos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Materiais Biocompatíveis / Seda Limite: Humans Idioma: En Revista: Int J Mol Sci Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Estados Unidos