Blood-brain barrier and brain fatty acid uptake: Role of arachidonic acid and PGE2.
J Neurochem
; 135(5): 845-8, 2015 Dec.
Article
em En
| MEDLINE
| ID: mdl-26383055
ABSTRACT
How do fatty acids enter the brain and what role, if any, do membrane and cytosolic fatty acid binding proteins have on facilitating this process? This is a fundamental question that many lipid neurochemists will freely admit they cannot answer in any kind of definitive manner. A study by Dalvi and colleagues in this issue of the Journal of Neurochemistry now adds to our knowledge in this field. Among other important observations, their experiments demonstrate that a physiological level of arachidonic acid (ARA), that could be associated with many different physiological and pathophysiological states, increases permeability in a model of the human blood brain barrier (BBB) in the absence of cytokines. This last point is very important as it suggests increases in BBB permeability may occur in situations other than those associated with increases in tumor necrosis factor a (TNFα) and interleukin1b (IL1ß), giving additional options for developing drugs impacting BBB permeability.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Permeabilidade Capilar
/
Dinoprostona
/
Ácido Araquidônico
/
Células Endoteliais
/
Receptores de Prostaglandina E Subtipo EP3
/
Receptores de Prostaglandina E Subtipo EP4
Tipo de estudo:
Prognostic_studies
Limite:
Humans
Idioma:
En
Revista:
J Neurochem
Ano de publicação:
2015
Tipo de documento:
Article
País de afiliação:
Estados Unidos