Assembly and function of spinal circuits for motor control.
Annu Rev Cell Dev Biol
; 31: 669-98, 2015.
Article
em En
| MEDLINE
| ID: mdl-26393773
ABSTRACT
Control of movement is a fundamental and complex task of the vertebrate nervous system, which relies on communication between circuits distributed throughout the brain and spinal cord. Many of the networks essential for the execution of basic locomotor behaviors are composed of discrete neuronal populations residing within the spinal cord. The organization and connectivity of these circuits is established through programs that generate functionally diverse neuronal subtypes, each contributing to a specific facet of motor output. Significant progress has been made in deciphering how neuronal subtypes are specified and in delineating the guidance and synaptic specificity determinants at the core of motor circuit assembly. Recent studies have shed light on the basic principles linking locomotor circuit connectivity with function, and they are beginning to reveal how more sophisticated motor behaviors are encoded. In this review, we discuss the impact of developmental programs in specifying motor behaviors governed by spinal circuits.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Medula Espinal
/
Atividade Motora
/
Rede Nervosa
Limite:
Animals
Idioma:
En
Revista:
Annu Rev Cell Dev Biol
Assunto da revista:
BIOLOGIA
Ano de publicação:
2015
Tipo de documento:
Article