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A Paradoxical Treatment for a Paradoxical Condition: Infliximab Use in Three Cases of Mycobacterial IRIS.
Hsu, Denise C; Faldetta, Kimberly F; Pei, Luxin; Sheikh, Virginia; Utay, Netanya S; Roby, Gregg; Rupert, Adam; Fauci, Anthony S; Sereti, Irini.
Afiliação
  • Hsu DC; National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, Maryland.
  • Faldetta KF; National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, Maryland.
  • Pei L; National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, Maryland.
  • Sheikh V; National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, Maryland.
  • Utay NS; Department of Internal Medicine, Division of Infectious Diseases, University of Texas Medical Branch, Galveston.
  • Roby G; National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, Maryland.
  • Rupert A; Leidos Biomedical Research, Inc, Frederick, Maryland.
  • Fauci AS; National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, Maryland.
  • Sereti I; National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, Maryland.
Clin Infect Dis ; 62(2): 258-261, 2016 Jan 15.
Article em En | MEDLINE | ID: mdl-26394669
The management of corticosteroid refractory immune reconstitution inflammatory syndrome (IRIS) is currently unclear. Infliximab administration was associated with clinical improvement without significant adverse events in 3 patients with mycobacterial IRIS. Immunologic and virologic responses to antiretroviral therapy were unaffected. Tumor necrosis factor blockade may be beneficial for IRIS and warrants further study in clinical trials.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Tuberculose / Síndrome Inflamatória da Reconstituição Imune / Infliximab / Fatores Imunológicos Limite: Adult / Humans / Male Idioma: En Revista: Clin Infect Dis Assunto da revista: DOENCAS TRANSMISSIVEIS Ano de publicação: 2016 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Tuberculose / Síndrome Inflamatória da Reconstituição Imune / Infliximab / Fatores Imunológicos Limite: Adult / Humans / Male Idioma: En Revista: Clin Infect Dis Assunto da revista: DOENCAS TRANSMISSIVEIS Ano de publicação: 2016 Tipo de documento: Article