Protective immunity against Brugia malayi infective larvae in mice. I. Parameters of active and passive immunity.
Am J Trop Med Hyg
; 41(6): 650-6, 1989 Dec.
Article
em En
| MEDLINE
| ID: mdl-2641642
ABSTRACT
Protective immunity against infective larvae of Brugia malayi was studied in different strains of mice using various sources of antigens. The following strains of mice were susceptible to infective larvae development for 2 weeks after primary ip challenge BALB/c, C3H/HeJ, C3H/NeN, C3H/HeJms, C57BL/6Jms, and DDD. In comparison to gerbils, BALB/c mice developed stronger resistance to infective larvae after immunization with irradiation attenuated larvae or with killed microfilariae (mf). However, killed mf failed to enhance resistance in C3H/HeJ mice, although C3H/HeN mice were strongly protected and C3H/HeJms mice were protected to a lesser degree by this antigen. Extracts of mf with phosphate buffered saline and sodium dodecyl sulfate both induced high levels of resistance in BALB/c mice. Transfer of resistance from BALB/c mice immunized with attenuated infective larvae to naive mice was accomplished at a high level at protection with nylon wool nonadherent spleen cells (T cells) but not with adherent cells treated with anti-Thy 1.2 serum and complement. In contrast, sera from immunized mice were much less protective.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Filariose Linfática
/
Brugia
/
Linfócitos T
/
Imunização Passiva
/
Imunização
/
Filariose
Limite:
Animals
Idioma:
En
Revista:
Am J Trop Med Hyg
Ano de publicação:
1989
Tipo de documento:
Article
País de afiliação:
Japão