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Establishment and validation of a 384-well antibacterial assay amenable for high-throughput screening and combination testing.
Mishra, Arti; Dobritsa, Svetlana V; Crouch, Marie-Laure; Rabenstein, John; Lee, Joycelyn Xiang Yi; Dhakshinamoorthy, Saravanakumar.
Afiliação
  • Mishra A; Biology and Pharmacology, Albany Molecular Research, Inc., The Galen, #05-01, 61 Science Park Road, 117525, Singapore.
  • Dobritsa SV; Biology and Pharmacology, Albany Molecular Research, Inc., The Galen, #05-01, 61 Science Park Road, 117525, Singapore; Lead Discovery, Albany Molecular Research, Inc., 22215 26th Avenue SE, Bothell, WA 98021, United States.
  • Crouch ML; Lead Discovery, Albany Molecular Research, Inc., 22215 26th Avenue SE, Bothell, WA 98021, United States.
  • Rabenstein J; Lead Discovery, Albany Molecular Research, Inc., 22215 26th Avenue SE, Bothell, WA 98021, United States.
  • Lee JX; Biology and Pharmacology, Albany Molecular Research, Inc., The Galen, #05-01, 61 Science Park Road, 117525, Singapore.
  • Dhakshinamoorthy S; Biology and Pharmacology, Albany Molecular Research, Inc., The Galen, #05-01, 61 Science Park Road, 117525, Singapore. Electronic address: Saravanakumar.Dhakshinamoorthy@amriglobal.com.
J Microbiol Methods ; 118: 173-5, 2015 Nov.
Article em En | MEDLINE | ID: mdl-26432950
ABSTRACT
A 384-well-based antibacterial assay amenable for high-throughput screening and combination testing is described. The assay uses 100-500nL of test compounds and tolerates up to 2.5% dimethyl sulfoxide concentrations. It can be used for screening compound libraries and testing combinatory/synergistic/antagonistic effects of antibiotics, small molecules, and natural product extracts.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Bactérias / Interações Medicamentosas / Avaliação Pré-Clínica de Medicamentos / Ensaios de Triagem em Larga Escala / Antibacterianos Tipo de estudo: Diagnostic_studies / Screening_studies Idioma: En Revista: J Microbiol Methods Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Singapura
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Bactérias / Interações Medicamentosas / Avaliação Pré-Clínica de Medicamentos / Ensaios de Triagem em Larga Escala / Antibacterianos Tipo de estudo: Diagnostic_studies / Screening_studies Idioma: En Revista: J Microbiol Methods Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Singapura