Schisandrae Fructus Inhibits IL-1ß-Induced Matrix Metalloproteinases and Inflammatory Mediators Production in SW1353 Human Chondrocytes by Suppressing NF-&#954;B and MAPK Activation.

Jeong, Jin-Woo; Lee, Hye Hyeon; Choi, Eun-Ok; Lee, Ki Won; Kim, Ki Young; Kim, Sung Goo; Hong, Su Hyun; Kim, Gi-Young; Park, Cheol; Kim, Ho Kyoung; Choi, Young Whan; Choi, Yung Hyun

Schisandrae Fructus Inhibits IL-1ß-Induced Matrix Metalloproteinases and Inflammatory Mediators Production in SW1353 Human Chondrocytes by Suppressing NF-κB and MAPK Activation.

Jeong, Jin-Woo; Lee, Hye Hyeon; Choi, Eun-Ok; Lee, Ki Won; Kim, Ki Young; Kim, Sung Goo; Hong, Su Hyun; Kim, Gi-Young; Park, Cheol; Kim, Ho Kyoung; Choi, Young Whan; Choi, Yung Hyun.

Afiliação

Jeong JW; Anti-Aging Research Center, Dongeui University, Busan, 614-714, Republic of Korea.
Lee HH; Department of Biochemistry, Dongeui University College of Korean Medicine, Busan, 614-052, Republic of Korea.
Choi EO; Anti-Aging Research Center, Dongeui University, Busan, 614-714, Republic of Korea.
Lee KW; Anti-Aging Research Center, Dongeui University, Busan, 614-714, Republic of Korea.
Kim KY; Research Institute, Bio-Port Korea INC, Marine Bio-Industry Development Center, Busan, 619-912, Republic of Korea.
Kim SG; Research Institute, Bio-Port Korea INC, Marine Bio-Industry Development Center, Busan, 619-912, Republic of Korea.
Hong SH; Research Institute, Bio-Port Korea INC, Marine Bio-Industry Development Center, Busan, 619-912, Republic of Korea.
Kim GY; Department of Biochemistry, Dongeui University College of Korean Medicine, Busan, 614-052, Republic of Korea.
Park C; Department of Marine Life Sciences, Laboratory of Immunobiology, Jeju National University, Jeju, 690-756, Republic of Korea.
Kim HK; Department of Molecular Biology, College of Natural Sciences and Human Ecology, Dongeui University, Busan, 614-714, Republic of Korea.
Choi YW; Herbal Medicine Research Division, Herbal Medicine Resources Group, Korea Institute of Oriental Medicine, Daejeon, 305-811, Republic of Korea.
Choi YH; Department of Horticultural Bioscience, College of Natural Resource and Life Sciences, Pusan National University, Miryang, 627-706, Republic of Korea.

Drug Dev Res ; 76(8): 474-83, 2015 Dec.

Article em En | MEDLINE | ID: mdl-26443270

Assuntos

Condrócitos/efeitos dos fármacos; Interleucina-1beta/antagonistas & inibidores; Metaloproteinases da Matriz/biossíntese; Proteínas Quinases Ativadas por Mitógeno/antagonistas & inibidores; NF-kappa B/antagonistas & inibidores; Extratos Vegetais/farmacologia; Schisandra/química; Linhagem Celular; Condrócitos/imunologia; Condrócitos/metabolismo; Ciclo-Oxigenase 2/metabolismo; Dinoprostona/metabolismo; Interações Medicamentosas; Indução Enzimática/efeitos dos fármacos; Frutas/química; Humanos; Mediadores da Inflamação/antagonistas & inibidores; Interleucina-1beta/farmacologia; Sistema de Sinalização das MAP Quinases/efeitos dos fármacos; Metaloproteinases da Matriz/metabolismo; Proteínas Quinases Ativadas por Mitógeno/metabolismo; NF-kappa B/metabolismo; Óxido Nítrico/metabolismo; Óxido Nítrico Sintase Tipo II/metabolismo; Osteoartrite/tratamento farmacológico; Fosforilação/efeitos dos fármacos

Palavras-chave

NF-κB; Schisandra chinensis; matrix metalloproteinase; mitogen-activated protein kinases; osteoarthritis

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Extratos Vegetais / NF-kappa B / Condrócitos / Metaloproteinases da Matriz / Proteínas Quinases Ativadas por Mitógeno / Schisandra / Interleucina-1beta Limite: Humans Idioma: En Revista: Drug Dev Res Ano de publicação: 2015 Tipo de documento: Article

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