Characterization and mutagenicity of 1-nitrosotryptophol and 6-nitrotryptophol possible genotoxic substances associated with smoking and alcohol consumption.
Cancer Lett
; 44(2): 109-16, 1989 Feb.
Article
em En
| MEDLINE
| ID: mdl-2646011
ABSTRACT
Tryptophol (Typ) is a minor product of tryptophane metabolism in humans which is increased with alcohol consumption. Typ can react rapidly with nitrite at pH 3.0 to form 1-nitrosotryptophol (NO-Typ) in high yield. This product is also formed in various organic solvents by the reaction of NO/NO2 mixtures with Typ. Under similar conditions, NO2 in the absence of NO will react with Typ to form 6-nitrotryptophol (NO2-Typ). Both products, NO-Typ and NO2-Typ, are mutagenic when tested in the absence of rat liver microsomes with a variety of Salmonella typhimurium tester strains.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Consumo de Bebidas Alcoólicas
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Fumar
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Indóis
Tipo de estudo:
Risk_factors_studies
Idioma:
En
Revista:
Cancer Lett
Ano de publicação:
1989
Tipo de documento:
Article
País de afiliação:
Japão