Macrophage inflammatory protein-1: a prostaglandin-independent endogenous pyrogen.
Science
; 243(4894 Pt 1): 1066-8, 1989 Feb 24.
Article
em En
| MEDLINE
| ID: mdl-2646711
ABSTRACT
Macrophage inflammatory protein-1 (MIP-1) produced a monophasic fever of rapid onset whose magnitude was equal to or greater than that of fevers produced with either recombinant human cachectin (or tumor necrosis factor) or recombinant human interleukin-1. However, in contrast to these two endogenous pyrogens, the fever induced by MIP-1 was not inhibited by the cyclooxygenase inhibitor ibuprofen. Thus, MIP-1 may participate in the febrile response that is not mediated through prostaglandin synthesis and clinically cannot be ablated by cyclooxygenase inhibitors.
Buscar no Google
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Fatores Quimiotáticos
/
Febre
Limite:
Animals
/
Female
/
Humans
Idioma:
En
Revista:
Science
Ano de publicação:
1989
Tipo de documento:
Article