The Akt-mTOR axis is a pivotal regulator of eccentric hypertrophy during volume overload.

Ikeda, Masataka; Ide, Tomomi; Fujino, Takeo; Matsuo, Yuka; Arai, Shinobu; Saku, Keita; Kakino, Takamori; Oga, Yasuhiro; Nishizaki, Akiko; Sunagawa, Kenji

Ikeda, Masataka; Ide, Tomomi; Fujino, Takeo; Matsuo, Yuka; Arai, Shinobu; Saku, Keita; Kakino, Takamori; Oga, Yasuhiro; Nishizaki, Akiko; Sunagawa, Kenji.

Afiliação

Ikeda M; Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Ide T; Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Fujino T; Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Matsuo Y; Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Arai S; Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Saku K; Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Kakino T; Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Oga Y; Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Nishizaki A; Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Sunagawa K; Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.

Sci Rep ; 5: 15881, 2015 Oct 30.

Article em En | MEDLINE | ID: mdl-26515499

Assuntos

Hipertrofia Ventricular Esquerda/fisiopatologia; Proteínas Proto-Oncogênicas c-akt/metabolismo; Serina-Treonina Quinases TOR/metabolismo; Animais; Fístula Arteriovenosa/metabolismo; Fístula Arteriovenosa/patologia; Ecocardiografia; Coração/fisiopatologia; Hemodinâmica/efeitos dos fármacos; Hipertrofia Ventricular Esquerda/metabolismo; Peptídeos e Proteínas de Sinalização Intercelular/genética; Peptídeos e Proteínas de Sinalização Intercelular/metabolismo; Camundongos; Camundongos Endogâmicos C57BL; Miocárdio/metabolismo; Fosforilação; Proteínas Proto-Oncogênicas c-akt/antagonistas & inibidores; Sirolimo/análogos & derivados; Sirolimo/farmacologia; Serina-Treonina Quinases TOR/antagonistas & inibidores; Ubiquitinação; Regulação para Cima/efeitos dos fármacos

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Hipertrofia Ventricular Esquerda / Proteínas Proto-Oncogênicas c-akt / Serina-Treonina Quinases TOR Limite: Animals Idioma: En Revista: Sci Rep Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Japão

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