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Oncosuppressive functions of tribbles pseudokinase 3.
Salazar, María; Lorente, Mar; Orea-Soufi, Alba; Dávila, David; Erazo, Tatiana; Lizcano, José; Carracedo, Arkaitz; Kiss-Toth, Endre; Velasco, Guillermo.
Afiliação
  • Salazar M; Department of Biochemistry and Molecular Biology I, School of Biology, Complutense University, 28040 Madrid, Spain Instituto de Investigaciones Sanitarias San Carlos (IdISSC), 28040 Madrid, Spain.
  • Lorente M; Department of Biochemistry and Molecular Biology I, School of Biology, Complutense University, 28040 Madrid, Spain Instituto de Investigaciones Sanitarias San Carlos (IdISSC), 28040 Madrid, Spain.
  • Orea-Soufi A; Department of Biochemistry and Molecular Biology I, School of Biology, Complutense University, 28040 Madrid, Spain Instituto de Investigaciones Sanitarias San Carlos (IdISSC), 28040 Madrid, Spain.
  • Dávila D; Department of Biochemistry and Molecular Biology I, School of Biology, Complutense University, 28040 Madrid, Spain Instituto de Investigaciones Sanitarias San Carlos (IdISSC), 28040 Madrid, Spain.
  • Erazo T; Departament de Bioquímica i Biologia Molecular, Institut de Neurociències, Universitat Autònoma de Barcelona, Cerdanyola del Vallés, Barcelona 08193, Spain.
  • Lizcano J; Departament de Bioquímica i Biologia Molecular, Institut de Neurociències, Universitat Autònoma de Barcelona, Cerdanyola del Vallés, Barcelona 08193, Spain.
  • Carracedo A; CIC bioGUNE, Bizkaia Technology Park, 48160 Derio, Spain Ikerbasque, Basque Foundation for Science, 48011 Bilbao, Spain Biochemistry and Molecular Biology Department, University of the Basque Country (UPV/EHU), 48940 Bilbao, Spain.
  • Kiss-Toth E; Department of Cardiovascular Science, University of Sheffield, Sheffield S10 2RX, U.K.
  • Velasco G; Department of Biochemistry and Molecular Biology I, School of Biology, Complutense University, 28040 Madrid, Spain Instituto de Investigaciones Sanitarias San Carlos (IdISSC), 28040 Madrid, Spain gvelasco@ucm.es.
Biochem Soc Trans ; 43(5): 1122-6, 2015 Oct.
Article em En | MEDLINE | ID: mdl-26517935
ABSTRACT
Tribbles pseudokinase 3 (TRIB3) belongs to the tribbles family of pseudokinases. In this article, we summarize several observation obtained by our laboratories supporting that TRIB3 plays a crucial role in the anti-cancer activity of cannabinoids (a novel family of potential anti-cancer agents derived from marijuana) and that TRIB3 genetic inactivation enhances cancer generation and progression.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas Repressoras / Transdução de Sinais / Proteínas Serina-Treonina Quinases / Proteínas de Ciclo Celular / Neoplasias Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: Biochem Soc Trans Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Espanha
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas Repressoras / Transdução de Sinais / Proteínas Serina-Treonina Quinases / Proteínas de Ciclo Celular / Neoplasias Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: Biochem Soc Trans Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Espanha