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Dissecting Polyclonal Vaccine-Induced Humoral Immunity against HIV Using Systems Serology.
Chung, Amy W; Kumar, Manu P; Arnold, Kelly B; Yu, Wen Han; Schoen, Matthew K; Dunphy, Laura J; Suscovich, Todd J; Frahm, Nicole; Linde, Caitlyn; Mahan, Alison E; Hoffner, Michelle; Streeck, Hendrik; Ackerman, Margaret E; McElrath, M Juliana; Schuitemaker, Hanneke; Pau, Maria G; Baden, Lindsey R; Kim, Jerome H; Michael, Nelson L; Barouch, Dan H; Lauffenburger, Douglas A; Alter, Galit.
Afiliação
  • Chung AW; Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA 02139, USA; Department of Microbiology and Immunology, Peter Doherty Institute, University of Melbourne, Parkville, VIC 3010, Australia.
  • Kumar MP; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
  • Arnold KB; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
  • Yu WH; Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA 02139, USA; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
  • Schoen MK; Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA 02139, USA.
  • Dunphy LJ; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
  • Suscovich TJ; Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA 02139, USA.
  • Frahm N; Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.
  • Linde C; Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA 02139, USA.
  • Mahan AE; Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA 02139, USA.
  • Hoffner M; Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA 02139, USA.
  • Streeck H; Department of Molecular Virology and Pathogenesis, Walter Reed Army Institute of Research, U.S. Military HIV Research Program, Silver Spring, MD 20910, USA; Institute for Medical Biology, University Hospital Essen, University Duisburg-Essen, Essen 45141, Germany.
  • Ackerman ME; Thayer School of Engineering at Dartmouth, Hanover, NH 03755, USA.
  • McElrath MJ; Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.
  • Schuitemaker H; Crucell Holland B.V., The Janssen Pharmaceutical Companies of Johnson & Johnson, Leiden 2333, the Netherlands.
  • Pau MG; Crucell Holland B.V., The Janssen Pharmaceutical Companies of Johnson & Johnson, Leiden 2333, the Netherlands.
  • Baden LR; Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA 02139, USA; Division of Infectious Diseases, Brigham and Women's Hospital, Boston, MA 02215, USA.
  • Kim JH; Department of Molecular Virology and Pathogenesis, Walter Reed Army Institute of Research, U.S. Military HIV Research Program, Silver Spring, MD 20910, USA; International Vaccine Institute, Seoul 151-742, Republic of Korea.
  • Michael NL; Department of Molecular Virology and Pathogenesis, Walter Reed Army Institute of Research, U.S. Military HIV Research Program, Silver Spring, MD 20910, USA.
  • Barouch DH; Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA 02139, USA; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
  • Lauffenburger DA; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. Electronic address: lauffen@mit.edu.
  • Alter G; Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA 02139, USA. Electronic address: galter@mgh.harvard.edu.
Cell ; 163(4): 988-98, 2015 Nov 05.
Article em En | MEDLINE | ID: mdl-26544943
ABSTRACT
While antibody titers and neutralization are considered the gold standard for the selection of successful vaccines, these parameters are often inadequate predictors of protective immunity. As antibodies mediate an array of extra-neutralizing Fc functions, when neutralization fails to predict protection, investigating Fc-mediated activity may help identify immunological correlates and mechanism(s) of humoral protection. Here, we used an integrative approach termed Systems Serology to analyze relationships among humoral responses elicited in four HIV vaccine trials. Each vaccine regimen induced a unique humoral "Fc fingerprint." Moreover, analysis of casecontrol data from the first moderately protective HIV vaccine trial, RV144, pointed to mechanistic insights into immune complex composition that may underlie protective immunity to HIV. Thus, multi-dimensional relational comparisons of vaccine humoral fingerprints offer a unique approach for the evaluation and design of novel vaccines against pathogens for which correlates of protection remain elusive.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Imunoglobulina G / Vacinas contra a AIDS / Anticorpos Antivirais Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Revista: Cell Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Austrália
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Imunoglobulina G / Vacinas contra a AIDS / Anticorpos Antivirais Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Revista: Cell Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Austrália