The clinical and therapeutic uses of MDM2 and PSMA and their potential interaction in aggressive cancers.
Biomark Med
; 9(12): 1353-70, 2015.
Article
em En
| MEDLINE
| ID: mdl-26581688
ABSTRACT
Prostate-specific membrane antigen (PSMA) overexpression is observed in the neovasculature of solid tumors, but not in the vasculature of normal tissues. Increased PSMA expression is positively associated with tumor stage and grade, although its function in cancer remains unclear. Mouse double minute 2 (MDM2) is a negative regulator of the p53 tumor suppressor and is reported to regulate VEGF expression and angiogenesis. Both proteins have been considered as biomarkers and therapeutic targets for advanced solid tumors. Our work and a recent microarray-based gene profiling study suggest there could be signaling interplay between MDM2 and PSMA. We herein review the mechanisms underlining the outgrowth of tumors associated with PSMA and MDM2, their potential interaction and how this may be applied to anticancer therapeutics.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Glutamato Carboxipeptidase II
/
Proteínas Proto-Oncogênicas c-mdm2
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Neoplasias
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Antígenos de Superfície
Limite:
Humans
Idioma:
En
Revista:
Biomark Med
Assunto da revista:
BIOQUIMICA
/
MEDICINA
Ano de publicação:
2015
Tipo de documento:
Article
País de afiliação:
Reino Unido