Teicoplanin inhibits Ebola pseudovirus infection in cell culture.
Antiviral Res
; 125: 1-7, 2016 Jan.
Article
em En
| MEDLINE
| ID: mdl-26585243
ABSTRACT
There is currently no approved antiviral therapy for treatment of Ebola virus disease. To discover readily available approved drugs that can be rapidly repurposed for treatment of Ebola virus infections, we screened 1280 FDA-approved drugs and identified glycopeptide antibiotic teicoplanin inhibiting Ebola pseudovirus infection by blocking virus entry in the low micromolar range. Teicoplanin could be evaluated further and incorporated into ongoing clinical studies.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Antivirais
/
Teicoplanina
/
Ebolavirus
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Antiviral Res
Ano de publicação:
2016
Tipo de documento:
Article
País de afiliação:
China