[Pooled Analysis of RET/PTC Gene Rearrangement Rate in Sporadic and Radiogenic Thyroid Papillary Carcinoma].
Radiats Biol Radioecol
; 55(4): 355-88, 2015.
Article
em Ru
| MEDLINE
| ID: mdl-26601537
ABSTRACT
The database of publications on molecular epidemiology of RET/PTC rearrangements in sporadic and radiogenic thyroid papillary carcinoma has been formed (197 sources at the end of 2014; coverage of 100%). Based on this database a pooled analysis of data on the rates of RET/PTC1, RET/PTC3 and RET/PTC in total was conducted. Statistical approach involves a simple pooling, as well as calculations on the models of random and fixed effects. Since almost all the strata were characterized by heterogeneity, simple pooling and random effect models were adequate. Calculations using both models led to almost identical results. For rates of RET/PTC1, RET/PTC3 and RET/PTC in total with respect to formed carcinoma striations the following values (pooling, in %) were obtained sporadic, total--13.2; 8.9; 21.2; sporadic, adults--13.3; 9.9; 21.1; sporadic, children--22.4; 17.5; 44.5; radiogenic, total--20.9; 20.3; 40.4; radiotherapy (exposure in childhood)--31.1; 11.8; 42.5; children affected after the Chernobyl accident--19.9; 23.6; 46.1; radiological incidents (exposure in adulthood)--19.9; 7.7; 18.4. Statistically proven is the reliability of differences of carcinoma indicators for children compared with adults (both sporadic and radiogenic tumors) and for radiogenic cancer compared with sporadic. The greatest increase in rate after irradiation was found for RET/PTC1, previously characterized in vitro as one of radiogenic types of RET/PTC.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Proteínas Tirosina Quinases
/
Neoplasias da Glândula Tireoide
/
Carcinoma
/
Rearranjo Gênico
/
Proteínas de Fusão Oncogênica
/
Bases de Dados Genéticas
/
Neoplasias Induzidas por Radiação
Tipo de estudo:
Etiology_studies
/
Systematic_reviews
Limite:
Adult
/
Child
/
Female
/
Humans
/
Male
Idioma:
Ru
Revista:
Radiats Biol Radioecol
Assunto da revista:
GENETICA
/
MEDICINA NUCLEAR
Ano de publicação:
2015
Tipo de documento:
Article