SUMOylation-Mediated Regulation of Cell Cycle Progression and Cancer.
Trends Biochem Sci
; 40(12): 779-793, 2015 Dec.
Article
em En
| MEDLINE
| ID: mdl-26601932
ABSTRACT
Protein conjugation with Small ubiquitin-like modifier (SUMOylation) has critical roles during cell cycle progression. Many important cell cycle regulators, including many oncogenes and tumor suppressors, are functionally regulated via SUMOylation. The dynamic SUMOylation pattern observed throughout the cell cycle is ensured via distinct spatial and temporal regulation of the SUMO machinery. Additionally, SUMOylation cooperates with other post-translational modifications to mediate cell cycle progression. Deregulation of these SUMOylation and deSUMOylation enzymes causes severe defects in cell proliferation and genome stability. Different types of cancer were recently shown to be dependent on a functioning SUMOylation system, a finding that could be exploited in anticancer therapies.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Ciclo Celular
/
Sumoilação
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Neoplasias
Limite:
Animals
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Humans
Idioma:
En
Revista:
Trends Biochem Sci
Ano de publicação:
2015
Tipo de documento:
Article