[HIV- DEMENTIA. A REVIEW THIRTY FIVE YEARS AFTER (1981-2015)]. / Demencia por HIV. Una revisión 35 años después (1981-2015).
Vertex
; 26(121): 195-201, 2015.
Article
em Es
| MEDLINE
| ID: mdl-26650556
ABSTRACT
In this review, the intention is to present the four clinical models of HIV-1-brain damage, named with the diffuse category of HIV-encephalopathy. It contains the past three decades, since the first static-infectological model of Snider WD, developed in 1983, based in a great neuropathological trial with AIDS patients. The second one, maybe the most compact of them, was the AIDS-dementia complex, published by the Navia BA group, in two notable papers published in 1986. This resulted in a consistent HIV-neuropsychiatric condition, till 1996, when HAART era begun. In a third early-HAART evolving model, we can find good correlations between the different levels clinical (mild-moderate/severe forms), neuropsychological (subcortical pattern), neuroimaging, and LCR-markers. In the last-current paradigm, coincident with the advanced HAART treatments, the original HIV-encephalopathy became in a hybrid-complex compartimentalized condition, in contact with other neurodegenerative entities, like Alzheimer disease, Parkinson disease or the CNS-immune reconstitution inflammatory syndrome, with a high prevalence, atypical clinical forms, and with the demand of a specific management, in parallel to the systemic HIV disease.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Complexo AIDS Demência
Tipo de estudo:
Diagnostic_studies
/
Etiology_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Humans
Idioma:
Es
Revista:
Vertex
Assunto da revista:
PSIQUIATRIA
Ano de publicação:
2015
Tipo de documento:
Article