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Evolution and Spread of Ebola Virus in Liberia, 2014-2015.
Ladner, Jason T; Wiley, Michael R; Mate, Suzanne; Dudas, Gytis; Prieto, Karla; Lovett, Sean; Nagle, Elyse R; Beitzel, Brett; Gilbert, Merle L; Fakoli, Lawrence; Diclaro, Joseph W; Schoepp, Randal J; Fair, Joseph; Kuhn, Jens H; Hensley, Lisa E; Park, Daniel J; Sabeti, Pardis C; Rambaut, Andrew; Sanchez-Lockhart, Mariano; Bolay, Fatorma K; Kugelman, Jeffrey R; Palacios, Gustavo.
Afiliação
  • Ladner JT; Center for Genome Sciences, US Army Medical Research Institute of Infectious Diseases, 1425 Porter Street, Fort Detrick, Frederick, MD, 21702, USA. Electronic address: jason.t.ladner.ctr@mail.mil.
  • Wiley MR; Center for Genome Sciences, US Army Medical Research Institute of Infectious Diseases, 1425 Porter Street, Fort Detrick, Frederick, MD, 21702, USA.
  • Mate S; Center for Genome Sciences, US Army Medical Research Institute of Infectious Diseases, 1425 Porter Street, Fort Detrick, Frederick, MD, 21702, USA.
  • Dudas G; Institute of Evolutionary Biology, University of Edinburgh, Ashworth Laboratories, Charlotte Auerbach Road, Edinburgh EH9 3FL, UK.
  • Prieto K; Center for Genome Sciences, US Army Medical Research Institute of Infectious Diseases, 1425 Porter Street, Fort Detrick, Frederick, MD, 21702, USA.
  • Lovett S; Center for Genome Sciences, US Army Medical Research Institute of Infectious Diseases, 1425 Porter Street, Fort Detrick, Frederick, MD, 21702, USA.
  • Nagle ER; Center for Genome Sciences, US Army Medical Research Institute of Infectious Diseases, 1425 Porter Street, Fort Detrick, Frederick, MD, 21702, USA.
  • Beitzel B; Center for Genome Sciences, US Army Medical Research Institute of Infectious Diseases, 1425 Porter Street, Fort Detrick, Frederick, MD, 21702, USA.
  • Gilbert ML; Molecular and Translational Sciences Division, US Army Medical Research Institute of Infectious Diseases, 1425 Porter Street, Fort Detrick, Frederick, MD, 21702, USA.
  • Fakoli L; Liberian Institute for Biomedical Research, Charlesville, Liberia.
  • Diclaro JW; Naval Medical Research Unit 3, 3A Imtidad Ramses Street, Cairo, Egypt 11517.
  • Schoepp RJ; Diagnostic Systems Division, US Army Medical Research Institute of Infectious Diseases, 1425 Porter Street, Fort Detrick, Frederick, MD, 21702, USA.
  • Fair J; MRI Global, 1330 Piccard Avenue, Rockville, MD, 20850, USA; The Huck Institutes of the Life Sciences, The Pennsylvania State University, University Park, PA 16802, USA.
  • Kuhn JH; Integrated Research Facility at Fort Detrick, National Institute of Allergy and Infectious Diseases, NIH, B-8200 Research Plaza, Fort Detrick, Frederick, MD, 21702, USA.
  • Hensley LE; Integrated Research Facility at Fort Detrick, National Institute of Allergy and Infectious Diseases, NIH, B-8200 Research Plaza, Fort Detrick, Frederick, MD, 21702, USA.
  • Park DJ; Broad Institute, 75 Ames St, Cambridge, MA, 02142, USA.
  • Sabeti PC; Broad Institute, 75 Ames St, Cambridge, MA, 02142, USA; Harvard University, 52 Oxford Street, Cambridge, MA, 02138, USA.
  • Rambaut A; Institute of Evolutionary Biology, University of Edinburgh, Ashworth Laboratories, Charlotte Auerbach Road, Edinburgh EH9 3FL, UK; Centre for Immunology, Infection and Evolution, University of Edinburgh, Ashworth Laboratories, Charlotte Auerbach Road, Edinburgh EH9 3FL, UK; Fogarty International Cen
  • Sanchez-Lockhart M; Center for Genome Sciences, US Army Medical Research Institute of Infectious Diseases, 1425 Porter Street, Fort Detrick, Frederick, MD, 21702, USA.
  • Bolay FK; Liberian Institute for Biomedical Research, Charlesville, Liberia.
  • Kugelman JR; Center for Genome Sciences, US Army Medical Research Institute of Infectious Diseases, 1425 Porter Street, Fort Detrick, Frederick, MD, 21702, USA.
  • Palacios G; Center for Genome Sciences, US Army Medical Research Institute of Infectious Diseases, 1425 Porter Street, Fort Detrick, Frederick, MD, 21702, USA. Electronic address: gustavo.f.palacios.ctr@mail.mil.
Cell Host Microbe ; 18(6): 659-69, 2015 Dec 09.
Article em En | MEDLINE | ID: mdl-26651942
ABSTRACT
The 2013-present Western African Ebola virus disease (EVD) outbreak is the largest ever recorded with >28,000 reported cases. Ebola virus (EBOV) genome sequencing has played an important role throughout this outbreak; however, relatively few sequences have been determined from patients in Liberia, the second worst-affected country. Here, we report 140 EBOV genome sequences from the second wave of the Liberian outbreak and analyze them in combination with 782 previously published sequences from throughout the Western African outbreak. While multiple early introductions of EBOV to Liberia are evident, the majority of Liberian EVD cases are consistent with a single introduction, followed by spread and diversification within the country. Movement of the virus within Liberia was widespread, and reintroductions from Liberia served as an important source for the continuation of the already ongoing EVD outbreak in Guinea. Overall, little evidence was found for incremental adaptation of EBOV to the human host.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doença pelo Vírus Ebola / Ebolavirus Limite: Humans País/Região como assunto: Africa Idioma: En Revista: Cell Host Microbe Assunto da revista: MICROBIOLOGIA Ano de publicação: 2015 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doença pelo Vírus Ebola / Ebolavirus Limite: Humans País/Região como assunto: Africa Idioma: En Revista: Cell Host Microbe Assunto da revista: MICROBIOLOGIA Ano de publicação: 2015 Tipo de documento: Article