Childhood adversity and cortical thickness and surface area in a population at familial high risk of schizophrenia.
Psychol Med
; 46(4): 891-6, 2016 Mar.
Article
em En
| MEDLINE
| ID: mdl-26654172
ABSTRACT
BACKGROUND:
There is now a well-established link between childhood adversity (CA) and schizophrenia. Similar structural abnormalities to those found in schizophrenia including alterations in grey-matter volume have also been shown in those who experience CA.METHOD:
We examined whether global estimates of cortical thickness or surface area were altered in those familial high-risk subjects who had been referred to a social worker or the Children's Panel compared to those who had not.RESULTS:
We found that the cortical surface area of those who were referred to the Children's Panel was significantly smaller than those who had not been referred, but cortical thickness was not significantly altered. There was also an effect of social work referral on cortical surface area but not on thickness.CONCLUSIONS:
Cortical surface area increases post-natally more than cortical thickness. Our findings suggest that CA can influence structural changes in the brain and it is likely to have a greater impact on cortical surface area than on cortical thickness.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Esquizofrenia
/
Córtex Cerebral
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Substância Cinzenta
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Adultos Sobreviventes de Eventos Adversos na Infância
Tipo de estudo:
Etiology_studies
/
Risk_factors_studies
Limite:
Adolescent
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Adult
/
Female
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Humans
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Male
Idioma:
En
Revista:
Psychol Med
Ano de publicação:
2016
Tipo de documento:
Article
País de afiliação:
Reino Unido