Promotion of a Ti-Mediated Mannich Reaction by a Proton Source.
J Org Chem
; 81(2): 723-8, 2016 Jan 15.
Article
em En
| MEDLINE
| ID: mdl-26656787
ABSTRACT
Low temperature NMR studies revealed that a diastereoselective Mannich reaction between a phenyl oxazolidone-derived titanium enolate and an aromatic aldimine was found to occur only after introduction of a proton source. While various protic additives could be used to promote the transformation, the best results were obtained using AcOH to afford the corresponding Mannich products in high diastereoselectivities and yields.
Texto completo:
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Coleções:
01-internacional
Base de dados:
MEDLINE
Idioma:
En
Revista:
J Org Chem
Ano de publicação:
2016
Tipo de documento:
Article
País de afiliação:
Estados Unidos