Native CB1 receptor affinity, intrinsic activity and accumbens shell dopamine stimulant properties of third generation SPICE/K2 cannabinoids: BB-22, 5F-PB-22, 5F-AKB-48 and STS-135.

De Luca, Maria Antonietta; Castelli, M Paola; Loi, Barbara; Porcu, Alessandra; Martorelli, Mariella; Miliano, Cristina; Kellett, Kathryn; Davidson, Colin; Stair, Jacqueline L; Schifano, Fabrizio; Di Chiara, Gaetano

De Luca, Maria Antonietta; Castelli, M Paola; Loi, Barbara; Porcu, Alessandra; Martorelli, Mariella; Miliano, Cristina; Kellett, Kathryn; Davidson, Colin; Stair, Jacqueline L; Schifano, Fabrizio; Di Chiara, Gaetano.

Afiliação

De Luca MA; Department of Biomedical Sciences, University of Cagliari, Italy. Electronic address: deluca@unica.it.
Castelli MP; Department of Biomedical Sciences, University of Cagliari, Italy.
Loi B; School of Life and Medical Sciences, University of Hertfordshire, UK.
Porcu A; Department of Biomedical Sciences, University of Cagliari, Italy.
Martorelli M; Department of Biomedical Sciences, University of Cagliari, Italy.
Miliano C; Department of Biomedical Sciences, University of Cagliari, Italy.
Kellett K; School of Life and Medical Sciences, University of Hertfordshire, UK.
Davidson C; Pharmacology and Cell Physiology, Division of Biomedical Science, St George's University of London, London, UK.
Stair JL; School of Life and Medical Sciences, University of Hertfordshire, UK.
Schifano F; School of Life and Medical Sciences, University of Hertfordshire, UK.
Di Chiara G; Department of Biomedical Sciences, University of Cagliari, Italy; CNR Institute of Neuroscience, Cagliari Section, University of Cagliari, Italy. Electronic address: dichiara@unica.it.

Neuropharmacology ; 105: 630-638, 2016 06.

Article em En | MEDLINE | ID: mdl-26686391

Assuntos

Adamantano/análogos & derivados; Agonistas de Receptores de Canabinoides/farmacologia; Dopaminérgicos/farmacologia; Indazóis/farmacologia; Indóis/farmacologia; Quinolinas/farmacologia; Adamantano/farmacologia; Animais; Antagonistas de Receptores de Canabinoides/farmacologia; Estimulantes do Sistema Nervoso Central/farmacologia; Relação Dose-Resposta a Droga; Avaliação Pré-Clínica de Medicamentos; Masculino; Camundongos Endogâmicos C57BL; Camundongos Knockout; Estrutura Molecular; Naftalenos/farmacologia; Núcleo Accumbens/efeitos dos fármacos; Núcleo Accumbens/metabolismo; Piperidinas/farmacologia; Córtex Pré-Frontal/efeitos dos fármacos; Córtex Pré-Frontal/metabolismo; Pirazóis/farmacologia; Ratos Sprague-Dawley; Receptor CB1 de Canabinoide/agonistas; Receptor CB1 de Canabinoide/antagonistas & inibidores; Receptor CB1 de Canabinoide/genética; Receptor CB1 de Canabinoide/metabolismo

Palavras-chave

CB1 receptors; Cannabinoids; Dopamine; GTPÎ³S binding; K2; Microdialysis; Spice

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Quinolinas / Adamantano / Dopaminérgicos / Agonistas de Receptores de Canabinoides / Indazóis / Indóis Limite: Animals Idioma: En Revista: Neuropharmacology Ano de publicação: 2016 Tipo de documento: Article

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