How Low Cholesterol Is Good for Anti-viral Immunity.
Cell
; 163(7): 1572-4, 2015 Dec 17.
Article
em En
| MEDLINE
| ID: mdl-26687349
ABSTRACT
York et al. identify a role for decreased cholesterol biosynthesis in virally infected cells as a critical event in the induction of the anti-viral response. The mechanism involves enhanced signaling by STING in the ER membrane in response to the second messenger cGAMP, promoting increased transcription of type I interferons. The authors suggest that a "lipid code" is being sensed by STING to allow it to signal.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Transdução de Sinais
/
Colesterol
/
Interferon gama
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Imunidade Inata
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Cell
Ano de publicação:
2015
Tipo de documento:
Article