Cytokine kinetics of Zika virus-infected patients from acute to reconvalescent phase.
Med Microbiol Immunol
; 205(3): 269-73, 2016 Jun.
Article
em En
| MEDLINE
| ID: mdl-26702627
ABSTRACT
Zika virus is an emerging mosquito-borne flavivirus currently causing large epidemics in the Pacific Ocean region and Brazil. Clinically, Zika fever resembles dengue fever, but is less severe. Whereas the clinical syndrome and laboratory diagnostic procedures have been described, little attention was paid to the immunology of the disease and its possible use for clinical follow-up of patients. Here, we investigate the role of cytokines in the pathogenesis of Zika fever in travelers returning from Asia, the Pacific, and Brazil. Polyfunctional T cell activation (Th1, Th2, Th9, and Th17 response) was seen during the acute phase characterized by respective cytokine level increases, followed by a decrease in the reconvalescent phase.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Citocinas
/
Infecção por Zika virus
Limite:
Adult
/
Female
/
Humans
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Male
/
Middle aged
País/Região como assunto:
America do sul
/
Asia
/
Brasil
/
Oceania
Idioma:
En
Revista:
Med Microbiol Immunol
Ano de publicação:
2016
Tipo de documento:
Article
País de afiliação:
Alemanha