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Conservative Secondary Shell Substitution In Cyclooxygenase-2 Reduces Inhibition by Indomethacin Amides and Esters via Altered Enzyme Dynamics.
Konkle, Mary E; Blobaum, Anna L; Moth, Christopher W; Prusakiewicz, Jeffery J; Xu, Shu; Ghebreselasie, Kebreab; Akingbade, Dapo; Jacobs, Aaron T; Rouzer, Carol A; Lybrand, Terry P; Marnett, Lawrence J.
Afiliação
  • Konkle ME; Departments of Biochemistry, ‡Chemistry, and §Pharmacology, Vanderbilt Institute of Chemical Biology, Center for Structural Biology, Center in Molecular Toxicology, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine , Nashville Tennessee 37232-0146, United States.
  • Blobaum AL; Departments of Biochemistry, ‡Chemistry, and §Pharmacology, Vanderbilt Institute of Chemical Biology, Center for Structural Biology, Center in Molecular Toxicology, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine , Nashville Tennessee 37232-0146, United States.
  • Moth CW; Departments of Biochemistry, ‡Chemistry, and §Pharmacology, Vanderbilt Institute of Chemical Biology, Center for Structural Biology, Center in Molecular Toxicology, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine , Nashville Tennessee 37232-0146, United States.
  • Prusakiewicz JJ; Departments of Biochemistry, ‡Chemistry, and §Pharmacology, Vanderbilt Institute of Chemical Biology, Center for Structural Biology, Center in Molecular Toxicology, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine , Nashville Tennessee 37232-0146, United States.
  • Xu S; Departments of Biochemistry, ‡Chemistry, and §Pharmacology, Vanderbilt Institute of Chemical Biology, Center for Structural Biology, Center in Molecular Toxicology, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine , Nashville Tennessee 37232-0146, United States.
  • Ghebreselasie K; Departments of Biochemistry, ‡Chemistry, and §Pharmacology, Vanderbilt Institute of Chemical Biology, Center for Structural Biology, Center in Molecular Toxicology, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine , Nashville Tennessee 37232-0146, United States.
  • Akingbade D; Departments of Biochemistry, ‡Chemistry, and §Pharmacology, Vanderbilt Institute of Chemical Biology, Center for Structural Biology, Center in Molecular Toxicology, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine , Nashville Tennessee 37232-0146, United States.
  • Jacobs AT; Departments of Biochemistry, ‡Chemistry, and §Pharmacology, Vanderbilt Institute of Chemical Biology, Center for Structural Biology, Center in Molecular Toxicology, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine , Nashville Tennessee 37232-0146, United States.
  • Rouzer CA; Departments of Biochemistry, ‡Chemistry, and §Pharmacology, Vanderbilt Institute of Chemical Biology, Center for Structural Biology, Center in Molecular Toxicology, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine , Nashville Tennessee 37232-0146, United States.
  • Lybrand TP; Departments of Biochemistry, ‡Chemistry, and §Pharmacology, Vanderbilt Institute of Chemical Biology, Center for Structural Biology, Center in Molecular Toxicology, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine , Nashville Tennessee 37232-0146, United States.
  • Marnett LJ; Departments of Biochemistry, ‡Chemistry, and §Pharmacology, Vanderbilt Institute of Chemical Biology, Center for Structural Biology, Center in Molecular Toxicology, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine , Nashville Tennessee 37232-0146, United States.
Biochemistry ; 55(2): 348-59, 2016 Jan 19.
Article em En | MEDLINE | ID: mdl-26704937
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Indometacina / Ésteres / Ciclo-Oxigenase 2 / Amidas Idioma: En Revista: Biochemistry Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Indometacina / Ésteres / Ciclo-Oxigenase 2 / Amidas Idioma: En Revista: Biochemistry Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Estados Unidos