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A mouse-human phase 1 co-clinical trial of a protease-activated fluorescent probe for imaging cancer.
Whitley, Melodi Javid; Cardona, Diana M; Lazarides, Alexander L; Spasojevic, Ivan; Ferrer, Jorge M; Cahill, Joan; Lee, Chang-Lung; Snuderl, Matija; Blazer, Dan G; Hwang, E Shelley; Greenup, Rachel A; Mosca, Paul J; Mito, Jeffrey K; Cuneo, Kyle C; Larrier, Nicole A; O'Reilly, Erin K; Riedel, Richard F; Eward, William C; Strasfeld, David B; Fukumura, Dai; Jain, Rakesh K; Lee, W David; Griffith, Linda G; Bawendi, Moungi G; Kirsch, David G; Brigman, Brian E.
Afiliação
  • Whitley MJ; Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC 27710, USA. Medical Science Training Program, Duke University Medical Center, Durham, NC 27710, USA.
  • Cardona DM; Department of Pathology, Duke University Medical Center, Durham, NC 27710, USA.
  • Lazarides AL; School of Medicine, Duke University Medical Center, Durham, NC 27710, USA.
  • Spasojevic I; Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA. PK/PD Core Laboratory, Duke Cancer Institute, Duke University Medical Center, Durham, NC 27710, USA.
  • Ferrer JM; Lumicell Inc., Wellesley, MA 02481, USA.
  • Cahill J; Department of Radiation Oncology, Duke University Medical Center, Durham, NC 27710, USA.
  • Lee CL; Department of Radiation Oncology, Duke University Medical Center, Durham, NC 27710, USA.
  • Snuderl M; Edwin L. Steele Laboratory, Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
  • Blazer DG; Department of Surgery, Duke University Medical Center, Durham, NC 27710, USA.
  • Hwang ES; Department of Surgery, Duke University Medical Center, Durham, NC 27710, USA.
  • Greenup RA; Department of Surgery, Duke University Medical Center, Durham, NC 27710, USA.
  • Mosca PJ; Department of Surgery, Duke University Medical Center, Durham, NC 27710, USA.
  • Mito JK; Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC 27710, USA. Medical Science Training Program, Duke University Medical Center, Durham, NC 27710, USA.
  • Cuneo KC; Department of Radiation Oncology, Duke University Medical Center, Durham, NC 27710, USA.
  • Larrier NA; Department of Radiation Oncology, Duke University Medical Center, Durham, NC 27710, USA.
  • O'Reilly EK; Duke Translational Medicine Institute, Regulatory Affairs Group, Duke University Medical Center, NC 27710, USA.
  • Riedel RF; Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA.
  • Eward WC; Department of Orthopaedic Surgery, Duke University Medical Center, Durham, NC 27710, USA.
  • Strasfeld DB; Lumicell Inc., Wellesley, MA 02481, USA.
  • Fukumura D; Edwin L. Steele Laboratory, Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
  • Jain RK; Edwin L. Steele Laboratory, Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
  • Lee WD; Lumicell Inc., Wellesley, MA 02481, USA.
  • Griffith LG; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02142, USA.
  • Bawendi MG; Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA 02142, USA.
  • Kirsch DG; Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC 27710, USA. Department of Radiation Oncology, Duke University Medical Center, Durham, NC 27710, USA. david.kirsch@duke.edu.
  • Brigman BE; Department of Orthopaedic Surgery, Duke University Medical Center, Durham, NC 27710, USA.
Sci Transl Med ; 8(320): 320ra4, 2016 Jan 06.
Article em En | MEDLINE | ID: mdl-26738797

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Peptídeo Hidrolases / Diagnóstico por Imagem / Corantes Fluorescentes / Neoplasias Tipo de estudo: Diagnostic_studies / Prognostic_studies Limite: Animals / Female / Humans Idioma: En Revista: Sci Transl Med Assunto da revista: CIENCIA / MEDICINA Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Estados Unidos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Peptídeo Hidrolases / Diagnóstico por Imagem / Corantes Fluorescentes / Neoplasias Tipo de estudo: Diagnostic_studies / Prognostic_studies Limite: Animals / Female / Humans Idioma: En Revista: Sci Transl Med Assunto da revista: CIENCIA / MEDICINA Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Estados Unidos