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White matter hyperintensity patterns in cerebral amyloid angiopathy and hypertensive arteriopathy.
Charidimou, Andreas; Boulouis, Gregoire; Haley, Kellen; Auriel, Eitan; van Etten, Ellis S; Fotiadis, Panagiotis; Reijmer, Yael; Ayres, Alison; Vashkevich, Anastasia; Dipucchio, Zora Y; Schwab, Kristin M; Martinez-Ramirez, Sergi; Rosand, Jonathan; Viswanathan, Anand; Greenberg, Steven M; Gurol, M Edip.
Afiliação
  • Charidimou A; From the Hemorrhagic Stroke Research Program, Department of Neurology, Massachusetts General Hospital Stroke Research Center (A.C., G.B., K.H., E.A., E.S.v.E., P.F., Y.R., A.A., A. Vashkevich, Z.Y.D., K.M.S., S.M.-R., J.R., A. Viswanathan, S.M.G., M.E.G.), and Division of Neurocritical Care and Emer
  • Boulouis G; From the Hemorrhagic Stroke Research Program, Department of Neurology, Massachusetts General Hospital Stroke Research Center (A.C., G.B., K.H., E.A., E.S.v.E., P.F., Y.R., A.A., A. Vashkevich, Z.Y.D., K.M.S., S.M.-R., J.R., A. Viswanathan, S.M.G., M.E.G.), and Division of Neurocritical Care and Emer
  • Haley K; From the Hemorrhagic Stroke Research Program, Department of Neurology, Massachusetts General Hospital Stroke Research Center (A.C., G.B., K.H., E.A., E.S.v.E., P.F., Y.R., A.A., A. Vashkevich, Z.Y.D., K.M.S., S.M.-R., J.R., A. Viswanathan, S.M.G., M.E.G.), and Division of Neurocritical Care and Emer
  • Auriel E; From the Hemorrhagic Stroke Research Program, Department of Neurology, Massachusetts General Hospital Stroke Research Center (A.C., G.B., K.H., E.A., E.S.v.E., P.F., Y.R., A.A., A. Vashkevich, Z.Y.D., K.M.S., S.M.-R., J.R., A. Viswanathan, S.M.G., M.E.G.), and Division of Neurocritical Care and Emer
  • van Etten ES; From the Hemorrhagic Stroke Research Program, Department of Neurology, Massachusetts General Hospital Stroke Research Center (A.C., G.B., K.H., E.A., E.S.v.E., P.F., Y.R., A.A., A. Vashkevich, Z.Y.D., K.M.S., S.M.-R., J.R., A. Viswanathan, S.M.G., M.E.G.), and Division of Neurocritical Care and Emer
  • Fotiadis P; From the Hemorrhagic Stroke Research Program, Department of Neurology, Massachusetts General Hospital Stroke Research Center (A.C., G.B., K.H., E.A., E.S.v.E., P.F., Y.R., A.A., A. Vashkevich, Z.Y.D., K.M.S., S.M.-R., J.R., A. Viswanathan, S.M.G., M.E.G.), and Division of Neurocritical Care and Emer
  • Reijmer Y; From the Hemorrhagic Stroke Research Program, Department of Neurology, Massachusetts General Hospital Stroke Research Center (A.C., G.B., K.H., E.A., E.S.v.E., P.F., Y.R., A.A., A. Vashkevich, Z.Y.D., K.M.S., S.M.-R., J.R., A. Viswanathan, S.M.G., M.E.G.), and Division of Neurocritical Care and Emer
  • Ayres A; From the Hemorrhagic Stroke Research Program, Department of Neurology, Massachusetts General Hospital Stroke Research Center (A.C., G.B., K.H., E.A., E.S.v.E., P.F., Y.R., A.A., A. Vashkevich, Z.Y.D., K.M.S., S.M.-R., J.R., A. Viswanathan, S.M.G., M.E.G.), and Division of Neurocritical Care and Emer
  • Vashkevich A; From the Hemorrhagic Stroke Research Program, Department of Neurology, Massachusetts General Hospital Stroke Research Center (A.C., G.B., K.H., E.A., E.S.v.E., P.F., Y.R., A.A., A. Vashkevich, Z.Y.D., K.M.S., S.M.-R., J.R., A. Viswanathan, S.M.G., M.E.G.), and Division of Neurocritical Care and Emer
  • Dipucchio ZY; From the Hemorrhagic Stroke Research Program, Department of Neurology, Massachusetts General Hospital Stroke Research Center (A.C., G.B., K.H., E.A., E.S.v.E., P.F., Y.R., A.A., A. Vashkevich, Z.Y.D., K.M.S., S.M.-R., J.R., A. Viswanathan, S.M.G., M.E.G.), and Division of Neurocritical Care and Emer
  • Schwab KM; From the Hemorrhagic Stroke Research Program, Department of Neurology, Massachusetts General Hospital Stroke Research Center (A.C., G.B., K.H., E.A., E.S.v.E., P.F., Y.R., A.A., A. Vashkevich, Z.Y.D., K.M.S., S.M.-R., J.R., A. Viswanathan, S.M.G., M.E.G.), and Division of Neurocritical Care and Emer
  • Martinez-Ramirez S; From the Hemorrhagic Stroke Research Program, Department of Neurology, Massachusetts General Hospital Stroke Research Center (A.C., G.B., K.H., E.A., E.S.v.E., P.F., Y.R., A.A., A. Vashkevich, Z.Y.D., K.M.S., S.M.-R., J.R., A. Viswanathan, S.M.G., M.E.G.), and Division of Neurocritical Care and Emer
  • Rosand J; From the Hemorrhagic Stroke Research Program, Department of Neurology, Massachusetts General Hospital Stroke Research Center (A.C., G.B., K.H., E.A., E.S.v.E., P.F., Y.R., A.A., A. Vashkevich, Z.Y.D., K.M.S., S.M.-R., J.R., A. Viswanathan, S.M.G., M.E.G.), and Division of Neurocritical Care and Emer
  • Viswanathan A; From the Hemorrhagic Stroke Research Program, Department of Neurology, Massachusetts General Hospital Stroke Research Center (A.C., G.B., K.H., E.A., E.S.v.E., P.F., Y.R., A.A., A. Vashkevich, Z.Y.D., K.M.S., S.M.-R., J.R., A. Viswanathan, S.M.G., M.E.G.), and Division of Neurocritical Care and Emer
  • Greenberg SM; From the Hemorrhagic Stroke Research Program, Department of Neurology, Massachusetts General Hospital Stroke Research Center (A.C., G.B., K.H., E.A., E.S.v.E., P.F., Y.R., A.A., A. Vashkevich, Z.Y.D., K.M.S., S.M.-R., J.R., A. Viswanathan, S.M.G., M.E.G.), and Division of Neurocritical Care and Emer
  • Gurol ME; From the Hemorrhagic Stroke Research Program, Department of Neurology, Massachusetts General Hospital Stroke Research Center (A.C., G.B., K.H., E.A., E.S.v.E., P.F., Y.R., A.A., A. Vashkevich, Z.Y.D., K.M.S., S.M.-R., J.R., A. Viswanathan, S.M.G., M.E.G.), and Division of Neurocritical Care and Emer
Neurology ; 86(6): 505-11, 2016 Feb 09.
Article em En | MEDLINE | ID: mdl-26747886
ABSTRACT

OBJECTIVE:

To identify different white matter hyperintensity (WMH) patterns between 2 hemorrhage-prone cerebral small vessel diseases (SVD) cerebral amyloid angiopathy (CAA) and hypertensive arteriopathy (HA).

METHODS:

Consecutive patients with SVD-related intracerebral hemorrhage (ICH) from a single-center prospective cohort were analyzed. Four predefined subcortical WMH patterns were compared between the CAA and HA groups. These WMH patterns were (1) multiple subcortical spots; (2) peri-basal ganglia (BG); (3) large posterior subcortical patches; and (4) anterior subcortical patches. Their associations with other imaging (cerebral microbleeds [CMBs], enlarged perivascular spaces [EPVS]) and clinical markers of SVD were investigated using multivariable logistic regression.

RESULTS:

The cohort included 319 patients with CAA and 137 patients with HA. Multiple subcortical spots prevalence was higher in the CAA compared to the HA group (29.8% vs 16.8%; p = 0.004). Peri-BG WMH pattern was more common in the HA- vs the CAA-ICH group (19% vs 7.8%; p = 0.001). In multivariable logistic regression, presence of multiple subcortical spots was associated with lobar CMBs (odds ratio [OR] 1.23; 95% confidence interval [CI] 1.01-1.50, p = 0.039) and high degree of centrum semiovale EPVS (OR 2.43; 95% CI 1.56-3.80, p < 0.0001). By contrast, age (OR 1.05; 95% CI 1.02-1.09, p = 0.002), deep CMBs (OR 2.46; 95% CI 1.44-4.20, p = 0.001), total WMH volume (OR 1.02; 95% CI 1.01-1.04, p = 0.002), and high BG EPVS degree (OR 8.81; 95% CI 3.37-23.02, p < 0.0001) were predictors of peri-BG WMH pattern.

CONCLUSION:

Different patterns of subcortical leukoaraiosis visually identified on MRI might provide insights into the dominant underlying microangiopathy type as well as mechanisms of tissue injury in patients with ICH.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Hemorragia Cerebral / Angiopatia Amiloide Cerebral / Substância Branca / Hipertensão Tipo de estudo: Diagnostic_studies / Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Neurology Ano de publicação: 2016 Tipo de documento: Article
Texto completo
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XML
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Hemorragia Cerebral / Angiopatia Amiloide Cerebral / Substância Branca / Hipertensão Tipo de estudo: Diagnostic_studies / Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Neurology Ano de publicação: 2016 Tipo de documento: Article