Palladium-Catalyzed Arylation of Unactivated γ-Methylene C(sp(3) )-H and δ-C-H Bonds with an Oxazoline-Carboxylate Auxiliary.
Chemistry
; 21(48): 17503-7, 2015 Nov 23.
Article
em En
| MEDLINE
| ID: mdl-26769628
ABSTRACT
A palladium-catalyzed arylation of unactivated γ-methylene C(sp(3) )H and remote δ-CH bonds by using an oxazoline-carboxylate directing group has been developed. Arylation occurs with a broad substrate scope and high tolerance of functional groups (i.e., halogen, nitro, cyano, ether, trifluoromethyl, amine, and ester). The oxazoline-type auxiliary can be removed under acidic conditions.
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1
Coleções:
01-internacional
Base de dados:
MEDLINE
Idioma:
En
Revista:
Chemistry
Assunto da revista:
QUIMICA
Ano de publicação:
2015
Tipo de documento:
Article