New approach towards the synthesis of selenosemicarbazones, useful compounds for Chagas' disease.
Eur J Med Chem
; 109: 107-13, 2016 Feb 15.
Article
em En
| MEDLINE
| ID: mdl-26774036
ABSTRACT
Herein, we describe a new approach towards the synthesis of selenosemicarbazones. The reaction involves an O-Se exchange of semicarbazones using Ishihara reagent. Eleven selenosemicarbazones were prepared using this methodology, with low to moderate yields. Among the prepared compounds the m-bromo phenyl methyl derivative 1b was selected to be evaluated in vivo, in a murine model of acute Chagas' disease. Compound 1b 10 mg/kg bw/day reduced 50% of parasitaemia profile compared with the control group, but was less effective than Benznidazole (50 mg/kg bw/day reduced 90%) and toxic. These studies are important to guide future Chagas drug design.
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Semicarbazonas
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Tripanossomicidas
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Compostos Organosselênicos
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Doença de Chagas
Limite:
Animals
Idioma:
En
Revista:
Eur J Med Chem
Ano de publicação:
2016
Tipo de documento:
Article
País de afiliação:
Uruguai