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Intrauterine growth restriction predicts lower lung function at school age in children born very preterm.
Ronkainen, Eveliina; Dunder, Teija; Kaukola, Tuula; Marttila, Riitta; Hallman, Mikko.
Afiliação
  • Ronkainen E; PEDEGO Research Center, and Medical Research Center Oulu, University of Oulu, Oulu, Finland Department of Children and Adolescents, Oulu University Hospital, Oulu, Finland.
  • Dunder T; Division of Allergology and Pulmonology, Department of Children and Adolescents, Oulu University Hospital, Oulu, Finland.
  • Kaukola T; Division of Neonatal Medicine, Department of Children and Adolescents, Oulu University Hospital, Oulu, Finland.
  • Marttila R; Division of Neonatal Medicine, Department of Children and Adolescents, Oulu University Hospital, Oulu, Finland.
  • Hallman M; PEDEGO Research Center, and Medical Research Center Oulu, University of Oulu, Oulu, Finland Division of Neonatal Medicine, Department of Children and Adolescents, Oulu University Hospital, Oulu, Finland.
Arch Dis Child Fetal Neonatal Ed ; 101(5): F412-7, 2016 Sep.
Article em En | MEDLINE | ID: mdl-26802110
OBJECTIVE: Children born preterm have lower lung function compared with term-born children. Intrauterine growth restriction (IUGR) may predispose individuals to chronic obstructive pulmonary disease. The purpose of this observational study was to investigate the role of IUGR as predictor of lung function at school age in children born very preterm. We further studied the difference in lung function between term-born and preterm-born children with distinct morbidities. DESIGN: Preterm-born children and age-matched and sex-matched term-born comparison groups (88 of each) were studied at the mean age of 11 years. Spirometry and diffusing capacity of the lung for carbon monoxide (DLCO) were recorded. All preterm-born subjects with IUGR (n=23), defined as birth weight less than -2 SD, were compared with preterm-born subjects without IUGR (n=65). RESULTS: In the preterm-born children exposed to IUGR, the forced expiratory volume in 1 s (FEV1) was 5.7 (95% CI -10.2 to -1.3) and DLCO 9.2 percentage points lower (95% CI -15.7 to -2.7) than in the preterm-born children with appropriate in utero growth (expressed as percentage of predicted values). The effect of IUGR in decreasing FEV1 and DLCO remained significant after adjustment for bronchopulmonary dysplasia (BPD). Further study indicated that after adjustment with IUGR and BPD, prematurity explained reduction in FEV1 but not in DLCO. CONCLUSIONS: In children born very preterm, IUGR is an independent risk factor for a lower lung function in school age. We propose that IUGR and BPD are the major early factors predisposing the children born very preterm to lower lung function.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Retardo do Crescimento Fetal / Lactente Extremamente Prematuro / Pulmão Tipo de estudo: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Child / Female / Humans / Male Idioma: En Revista: Arch Dis Child Fetal Neonatal Ed Assunto da revista: PEDIATRIA / PERINATOLOGIA Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Finlândia

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Retardo do Crescimento Fetal / Lactente Extremamente Prematuro / Pulmão Tipo de estudo: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Child / Female / Humans / Male Idioma: En Revista: Arch Dis Child Fetal Neonatal Ed Assunto da revista: PEDIATRIA / PERINATOLOGIA Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Finlândia